Antibody-Targeted Cyclodextrin-Based Nanoparticles for siRNA Delivery in the Treatment of Acute Myeloid Leukemia: Physicochemical Characteristics, in Vitro Mechanistic …

J Guo, EG Russell, R Darcy, TG Cotter… - Molecular …, 2017 - ACS Publications
Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults and is
associated with high relapse rates. It is known that leukemia stem cells (LSCs), a very small …

Role of surface modification in zinc oxide nanoparticles and its toxicity assessment toward human dermal fibroblast cells

M Ramasamy, M Das, SSA An, DK Yi - International journal of …, 2014 - Taylor & Francis
The wide-scale applications of zinc oxide (ZnO) nanoparticles (NPs) in photocatalysts, gas
sensors, and cosmetics may cause toxicity to humans and environments. Therefore, the aim …

Alternative in vitro assays in nanomaterial toxicology

T Hartung, E Sabbioni - Wiley Interdisciplinary Reviews …, 2011 - Wiley Online Library
Nanomaterials are acclaimed for their novel properties, for which broad new uses are being
discovered with increasing frequency. It is obvious that, as the properties change, unwanted …

Cytotoxic effects of nanoparticles assessed in vitro and in vivo

KE Cha, HJ Myung - Journal of Microbiology and Biotechnology, 2007 - koreascience.kr
An increasing number of applications is being developed for the use of nanoparticles in
various fields. We investigated possible toxicities of nanoparticles in cell culture and in mice …

Effects of hydrophobic core components in amphiphilic PDMAEMA nanoparticles on siRNA delivery

S Han, Q Cheng, Y Wu, J Zhou, X Long, T Wei… - Biomaterials, 2015 - Elsevier
Due to their biodegradable character, polyesters such as polycaprolactone (PCL), poly (d, l-
lactide)(PDLLA), and polylactic-co-glycolic acid (PLGA) were widely used as the …

Development of chitosan nanoparticles as drug delivery system for a prototype capsid inhibitor

M Xue, S Hu, Y Lu, Y Zhang, X Jiang, S An… - International Journal of …, 2015 - Elsevier
Oral delivery of biopharmaceutics drug disposition classification system (BDDCS) Class II or
IV drugs with poor aqueous solubility and poor enzymatic and/or metabolic stability is very …

A bottom-up approach to understanding protein layer formation at solid–liquid interfaces

M Kastantin, BB Langdon, DK Schwartz - Advances in colloid and interface …, 2014 - Elsevier
A common goal across different fields (eg separations, biosensors, biomaterials,
pharmaceuticals) is to understand how protein behavior at solid–liquid interfaces is affected …

Novel nanotechnology approaches to diagnosis and therapy of ovarian cancer

PS Kim, S Djazayeri, R Zeineldin - Gynecologic Oncology, 2011 - Elsevier
OBJECTIVE: Ovarian carcinoma is the leading cause of death from gynecologic
malignancies, which is a direct outcome of missing its diagnosis at an early stage …

Cellular uptake pathways of lipid-modified cationic polymers in gene delivery to primary cells

CYM Hsu, H Uludağ - Biomaterials, 2012 - Elsevier
Hydrophobic modifications have emerged as a promising approach to improve the efficiency
of non-viral gene delivery vectors (GDV). Functional GDVs from non-toxic polymers have …

Polyethylene glycol-modified arachidyl chitosan-based nanoparticles for prolonged blood circulation of doxorubicin

U Termsarasab, IS Yoon, JH Park, HT Moon… - International journal of …, 2014 - Elsevier
Doxorubicin (DOX)-loaded nanoparticles based on polyethylene glycol-conjugated chitosan
oligosaccharide-arachidic acid (CSOAA-PEG) were explored for potential application to …