Immune responses to stroke: mechanisms, modulation, and therapeutic potential

C Iadecola, MS Buckwalter… - The Journal of clinical …, 2020 - Am Soc Clin Investig
Stroke is the second leading cause of death worldwide and a leading cause of disability.
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …

Aging microbiota-gut-brain axis in stroke risk and outcome

P Honarpisheh, RM Bryan, LD McCullough - Circulation research, 2022 - Am Heart Assoc
The microbiota-gut-brain-axis (MGBA) is a bidirectional communication network between gut
microbes and their host. Many environmental and host-related factors affect the gut …

[HTML][HTML] Interventions targeting racial/ethnic disparities in stroke prevention and treatment

DA Levine, PW Duncan, MN Nguyen-Huynh… - Stroke, 2020 - journals.lww.com
Systemic racism is a public health crisis. Systemic racism and racial/ethnic injustice produce
racial/ethnic disparities in health care and health. Substantial racial/ethnic disparities in …

Evidence-based disparities in stroke care metrics and outcomes in the United States: a systematic review

S Ikeme, E Kottenmeier, G Uzochukwu, W Brinjikji - Stroke, 2022 - Am Heart Assoc
Stroke disproportionately affects racial minorities, and the level to which stroke treatment
practices differ across races is understudied. Here, we performed a systematic review of …

Strategies to reduce racial and ethnic inequities in stroke preparedness, care, recovery, and risk factor control: a scientific statement from the American Heart …

A Towfighi, B Boden-Albala, S Cruz-Flores… - Stroke, 2023 - Am Heart Assoc
Stroke is a disease of disparities, with tremendous racial and ethnic inequities in incidence,
prevalence, treatment, and outcomes. The accumulating literature on the relationship …

Toward a better understanding of sex-and gender-related differences in endovascular stroke treatment: a scientific statement from the American Heart Association …

JM Ospel, JD Schaafsma, TM Leslie-Mazwi… - Stroke, 2022 - Am Heart Assoc
There are many unknowns when it comes to the role of sex in the pathophysiology and
management of acute ischemic stroke. This is particularly true for endovascular treatment …

Acute ischemic stroke interventions in the United States and racial, socioeconomic, and geographic disparities

A de Havenon, K Sheth, KC Johnston, A Delic… - Neurology, 2021 - AAN Enterprises
Background and Objectives In patients with ischemic stroke (IS), IV alteplase (tissue
plasminogen activator tPA) and endovascular thrombectomy (EVT) reduce long-term …

[HTML][HTML] Access to mechanical thrombectomy for ischemic stroke in the United States

H Kamel, NS Parikh, A Chatterjee, LK Kim, JL Saver… - Stroke, 2021 - journals.lww.com
Background and Purpose: Mechanical thrombectomy helps prevent disability in patients with
acute ischemic stroke involving occlusion of a large cerebral vessel. Thrombectomy requires …

Temporal trends in racial and ethnic disparities in endovascular therapy in acute ischemic stroke

F Sheriff, H Xu, A Maud, V Gupta… - Journal of the …, 2022 - Am Heart Assoc
Introduction Endovascular therapy (EVT) use increased following clinical trials publication in
2015, but limited data suggest there may be persistent race and ethnicity differences …

Post-ischemic ubiquitination at the postsynaptic density reversibly influences the activity of ischemia-relevant kinases

L Dhawka, V Palfini, E Hambright, I Blanco… - Communications …, 2024 - nature.com
Ubiquitin modifications alter protein function and stability, thereby regulating cell
homeostasis and viability, particularly under stress. Ischemic stroke induces protein …