In aerobes, oxygen is essential for maintenance of life. However, incomplete reduction of
oxygen leads to generation of reactive oxygen species. These oxidants oxidise biological …

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors, initially
described as molecular targets for synthetic compounds inducing peroxisome proliferation …

Hormones have been considered as key factors involved in the maintenance of the redox
status of the body. We are making considerable progress in understanding interactions …

Background Although testosterone deficiency is associated with increased risks of heart
disease, the benefits of testosterone therapy are controversial. Moreover, current …

The value of testosterone replacement therapy (TRT) for older men is currently a topic of
intense debate. While US testosterone prescriptions have tripled in the past decade (9) …

Men are at greater risk for renal injury and dysfunction after acute ischemia-reperfusion (I/R)
than are women. Studies in animals suggest that the reason for the sex difference in renal …

Oxidative stress, resulting from dysregulation in the secretion of adrenal hormones,
represents a major concern in human health. The present review comprehensively …

The cardiovascular system is particularly sensitive to androgens, but some controversies
exist regarding the effect of testosterone on the heart. While among anabolic abusers, cases …

Testosterone deficiency (TD) has become a frequently diagnosed condition in our current
society with an obesity epidemic. Men diagnosed with TD often have co-morbidities …

Cardiovascular disease (CVD), including ischemic heart disease, remains a major
international public health problem (1). From an epidemiologic perspective, mitigation of …