Genome-wide association studies (GWAS) provide biological insights into disease onset
and progression and have potential to produce clinically useful biomarkers. A growing body …

Schizophrenia (SCZ) is a debilitating neuropsychiatric disorder with high heritability and
complex inheritance. In the past decade, successful identification of numerous susceptibility …

With new data about different aspects of schizophrenia being continually generated, it
becomes necessary to periodically revisit exactly what we know. Along with a need to review …

Schizophrenia is a complex and often chronic psychiatric disorder with high heritability.
Diagnosis of schizophrenia is still made clinically based on psychiatric symptoms; no …

Schizophrenia is a severe psychiatric disorder characterized by emotional, behavioral and
cognitive disturbances, and the treatment of schizophrenia is often complicated by …

Background Psychiatry aspires to the molecular understanding of its disorders and, with that
knowledge, to precision medicine. Research supporting such goals in the dimension of …

The dopaminergic neuromodulator system is fundamental to brain functions. Abnormal
dopamine (DA) pathway is implicated in psychiatric disorders, including schizophrenia (SZ) …

The risk of depression could be evaluated through its multifactorial nature using the
polygenic score (PGS) approach. Assuming a “clinical continuum” hypothesis of mental …

Schizophrenia is a heterogeneous disorder, exhibiting variability in presentation and
outcomes that complicate treatment and recovery. To explore this heterogeneity, we …

De novo protein synthesis is required for synapse modifications underlying stable memory
encoding. Yet neurons are highly compartmentalized cells and how protein synthesis can be …