Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials
Spinal cord injury is a severely disabling neurological condition leading to impaired mobility,
pain, and autonomic dysfunction. Most often, a single traumatic event, such as a traffic or …
pain, and autonomic dysfunction. Most often, a single traumatic event, such as a traffic or …
Advances in biomaterial‐based spinal cord injury repair
H Shen, C Fan, Z You, Z Xiao… - Advanced Functional …, 2022 - Wiley Online Library
Spinal cord injury (SCI) often leads to the loss of motor and sensory functions and is a major
challenge in neurological clinical practice. Understanding the pathophysiological changes …
challenge in neurological clinical practice. Understanding the pathophysiological changes …
Spinal cord tissue engineering via covalent interaction between biomaterials and cells
W Liu, B Xu, S Zhao, S Han, R Quan, W Liu, C Ji… - Science …, 2023 - science.org
Noncovalent interactions between cells and environmental cues have been recognized as
fundamental physiological interactions that regulate cell behavior. However, the effects of …
fundamental physiological interactions that regulate cell behavior. However, the effects of …
[HTML][HTML] A conductive supramolecular hydrogel creates ideal endogenous niches to promote spinal cord injury repair
B Yang, C Liang, D Chen, F Cheng, Y Zhang, S Wang… - Bioactive materials, 2022 - Elsevier
The current effective method for treatment of spinal cord injury (SCI) is to reconstruct the
biological microenvironment by filling the injured cavity area and increasing neuronal …
biological microenvironment by filling the injured cavity area and increasing neuronal …
Wireless charging-mediated angiogenesis and nerve repair by adaptable microporous hydrogels from conductive building blocks
Traumatic brain injury causes inflammation and glial scarring that impede brain tissue
repair, so stimulating angiogenesis and recovery of brain function remain challenging. Here …
repair, so stimulating angiogenesis and recovery of brain function remain challenging. Here …
3D printed collagen/silk fibroin scaffolds carrying the secretome of human umbilical mesenchymal stem cells ameliorated neurological dysfunction after spinal cord …
C Chen, HH Xu, XY Liu, YS Zhang… - Regenerative …, 2022 - academic.oup.com
Although implantation of biomaterials carrying mesenchymal stem cells (MSCs) is
considered as a promising strategy for ameliorating neural function after spinal cord injury …
considered as a promising strategy for ameliorating neural function after spinal cord injury …
The roles and applications of neural stem cells in spinal cord injury repair
W Guo, X Zhang, J Zhai, J Xue - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Spinal cord injury (SCI), which has no current cure, places a severe burden on patients.
Stem cell-based therapies are considered promising in attempts to repair injured spinal …
Stem cell-based therapies are considered promising in attempts to repair injured spinal …
A hyaluronic acid/silk fibroin/poly-dopamine-coated biomimetic hydrogel scaffold with incorporated neurotrophin-3 for spinal cord injury repair
Q Sha, Y Wang, Z Zhu, H Wang, H Qiu, W Niu, X Li… - Acta Biomaterialia, 2023 - Elsevier
Bio-factor stimulation is essential for axonal regeneration in the central nervous system.
Thus, persistent and efficient factor delivery in the local microenvironment is an ideal …
Thus, persistent and efficient factor delivery in the local microenvironment is an ideal …
NSC-derived extracellular matrix-modified GelMA hydrogel fibrous scaffolds for spinal cord injury repair
Z Chen, L Wang, C Chen, J Sun, J Luo, W Cui… - NPG Asia …, 2022 - nature.com
Cell-derived extracellular matrix (ECM) has been applied in spinal cord injury (SCI)
regeneration because of its various biological functions. However, insufficient mechanical …
regeneration because of its various biological functions. However, insufficient mechanical …
Neural stem cell therapies for spinal cord injury repair: an update on recent preclinical and clinical advances
SM Hosseini, B Borys, S Karimi-Abdolrezaee - Brain, 2024 - academic.oup.com
Traumatic spinal cord injury (SCI) is a leading cause of lifelong disabilities. Permanent
sensory, motor and autonomic impairments after SCI are substantially attributed to …
sensory, motor and autonomic impairments after SCI are substantially attributed to …