Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials

CM Zipser, JJ Cragg, JD Guest, MG Fehlings… - The Lancet …, 2022 - thelancet.com
Spinal cord injury is a severely disabling neurological condition leading to impaired mobility,
pain, and autonomic dysfunction. Most often, a single traumatic event, such as a traffic or …

Advances in biomaterial‐based spinal cord injury repair

H Shen, C Fan, Z You, Z Xiao… - Advanced Functional …, 2022 - Wiley Online Library
Spinal cord injury (SCI) often leads to the loss of motor and sensory functions and is a major
challenge in neurological clinical practice. Understanding the pathophysiological changes …

Spinal cord tissue engineering via covalent interaction between biomaterials and cells

W Liu, B Xu, S Zhao, S Han, R Quan, W Liu, C Ji… - Science …, 2023 - science.org
Noncovalent interactions between cells and environmental cues have been recognized as
fundamental physiological interactions that regulate cell behavior. However, the effects of …

[HTML][HTML] A conductive supramolecular hydrogel creates ideal endogenous niches to promote spinal cord injury repair

B Yang, C Liang, D Chen, F Cheng, Y Zhang, S Wang… - Bioactive materials, 2022 - Elsevier
The current effective method for treatment of spinal cord injury (SCI) is to reconstruct the
biological microenvironment by filling the injured cavity area and increasing neuronal …

Wireless charging-mediated angiogenesis and nerve repair by adaptable microporous hydrogels from conductive building blocks

RS Hsu, SJ Li, JH Fang, IC Lee, LA Chu, YC Lo… - Nature …, 2022 - nature.com
Traumatic brain injury causes inflammation and glial scarring that impede brain tissue
repair, so stimulating angiogenesis and recovery of brain function remain challenging. Here …

3D printed collagen/silk fibroin scaffolds carrying the secretome of human umbilical mesenchymal stem cells ameliorated neurological dysfunction after spinal cord …

C Chen, HH Xu, XY Liu, YS Zhang… - Regenerative …, 2022 - academic.oup.com
Although implantation of biomaterials carrying mesenchymal stem cells (MSCs) is
considered as a promising strategy for ameliorating neural function after spinal cord injury …

The roles and applications of neural stem cells in spinal cord injury repair

W Guo, X Zhang, J Zhai, J Xue - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Spinal cord injury (SCI), which has no current cure, places a severe burden on patients.
Stem cell-based therapies are considered promising in attempts to repair injured spinal …

A hyaluronic acid/silk fibroin/poly-dopamine-coated biomimetic hydrogel scaffold with incorporated neurotrophin-3 for spinal cord injury repair

Q Sha, Y Wang, Z Zhu, H Wang, H Qiu, W Niu, X Li… - Acta Biomaterialia, 2023 - Elsevier
Bio-factor stimulation is essential for axonal regeneration in the central nervous system.
Thus, persistent and efficient factor delivery in the local microenvironment is an ideal …

NSC-derived extracellular matrix-modified GelMA hydrogel fibrous scaffolds for spinal cord injury repair

Z Chen, L Wang, C Chen, J Sun, J Luo, W Cui… - NPG Asia …, 2022 - nature.com
Cell-derived extracellular matrix (ECM) has been applied in spinal cord injury (SCI)
regeneration because of its various biological functions. However, insufficient mechanical …

Neural stem cell therapies for spinal cord injury repair: an update on recent preclinical and clinical advances

SM Hosseini, B Borys, S Karimi-Abdolrezaee - Brain, 2024 - academic.oup.com
Traumatic spinal cord injury (SCI) is a leading cause of lifelong disabilities. Permanent
sensory, motor and autonomic impairments after SCI are substantially attributed to …