Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?

M Kou, L Huang, J Yang, Z Chiang, S Chen, J Liu… - Cell Death & …, 2022 - nature.com
Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone
marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and …

A paradigm shift in cell-free approach: the emerging role of MSCs-derived exosomes in regenerative medicine

S Moghadasi, M Elveny, HS Rahman… - Journal of translational …, 2021 - Springer
Recently, mesenchymal stem/stromal cells (MSCs) due to their pro-angiogenic, anti-
apoptotic, and immunoregulatory competencies along with fewer ethical issues are …

The application of mesenchymal stromal cells (MSCs) and their derivative exosome in skin wound healing: a comprehensive review

D Bian, Y Wu, G Song, R Azizi, A Zamani - Stem Cell Research & Therapy, 2022 - Springer
Recently, mesenchymal stromal cells (MSCs) and also their exosome has become a game-
changing tool in the context of tissue engineering and regenerative medicine. MSCs due to …

[HTML][HTML] The immune microenvironment in cartilage injury and repair

M Li, H Yin, Z Yan, H Li, J Wu, Y Wang, F Wei, G Tian… - Acta Biomaterialia, 2022 - Elsevier
The ability of articular cartilage to repair itself is limited because it lacks blood vessels,
nerves, and lymph tissue. Once damaged, it can lead to joint swelling and pain, accelerating …

Clinical applications of stem cell-derived exosomes

F Tan, X Li, Z Wang, J Li, K Shahzad… - Signal Transduction and …, 2024 - nature.com
Although stem cell-based therapy has demonstrated considerable potential to manage
certain diseases more successfully than conventional surgery, it nevertheless comes with …

Treatment of spinal cord injury with mesenchymal stem cells

LL Liau, QH Looi, WC Chia, T Subramaniam, MH Ng… - Cell & bioscience, 2020 - Springer
Background Spinal cord injury (SCI) is the damage to the spinal cord that can lead to
temporary or permanent loss of function due to injury to the nerve. The SCI patients are often …

Mesenchymal stem cell-derived exosomes: therapeutic opportunities and challenges for spinal cord injury

W Liu, Z Ma, J Li, X Kang - Stem cell research & therapy, 2021 - Springer
Spinal cord injury (SCI) often leads to serious motor and sensory dysfunction of the limbs
below the injured segment. SCI not only results in physical and psychological harm to …

Dental pulp stem cell-derived exosomes suppress M1 macrophage polarization through the ROS-MAPK-NFκB P65 signaling pathway after spinal cord injury

C Liu, F Hu, G Jiao, Y Guo, P Zhou, Y Zhang… - Journal of …, 2022 - Springer
Stem cell-derived exosomes have recently been regarded as potential drugs for treating
spinal cord injury (SCI) by reducing reactive oxygen species (ROS) and suppressing M1 …

Extracellular vesicles derived from hypoxia-preconditioned olfactory mucosa mesenchymal stem cells enhance angiogenesis via miR-612

L Ge, C Xun, W Li, S Jin, Z Liu, Y Zhuo, D Duan… - Journal of …, 2021 - Springer
Mesenchymal stem cells (MSCs) play important roles in tissue repair and regeneration, such
as the induction of angiogenesis, particularly under hypoxic conditions. However, the …

Hypoxic hUCMSC-derived extracellular vesicles attenuate allergic airway inflammation and airway remodeling in chronic asthma mice

L Dong, Y Wang, T Zheng, Y Pu, Y Ma, X Qi… - Stem Cell Research & …, 2021 - Springer
Background As one of the main functional forms of mesenchymal stem cells (MSCs), MSC-
derived extracellular vesicles (MSC-EVs) have shown an alternative therapeutic option in …