The promise and challenge of therapeutic genome editing
JA Doudna - Nature, 2020 - nature.com
Genome editing, which involves the precise manipulation of cellular DNA sequences to alter
cell fates and organism traits, has the potential to both improve our understanding of human …
cell fates and organism traits, has the potential to both improve our understanding of human …
Gene editing and CRISPR in the clinic: current and future perspectives
Genome editing technologies, particularly those based on zinc-finger nucleases (ZFNs),
transcription activator-like effector nucleases (TALENs), and CRISPR (clustered regularly …
transcription activator-like effector nucleases (TALENs), and CRISPR (clustered regularly …
Ready for repair? Gene editing enters the clinic for the treatment of human disease
MPT Ernst, M Broeders, P Herrero-Hernandez… - … Therapy Methods & …, 2020 - cell.com
We present an overview of clinical trials involving gene editing using clustered interspaced
short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9), transcription …
short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9), transcription …
Bioethical issues in genome editing by CRISPR-Cas9 technology
Genome editing technologies have led to fundamental changes in genetic science. Among
them, CRISPR-Cas9 technology particularly stands out due to its advantages such as easy …
them, CRISPR-Cas9 technology particularly stands out due to its advantages such as easy …
Do CRISPR germline ethics statements cut it?
C Brokowski - The CRISPR journal, 2018 - liebertpub.com
The extraordinary wave of genomic-engineering innovation, driven by CRISPR-Cas9, has
sparked worldwide scientific and ethical uncertainty. Great concern has arisen across the …
sparked worldwide scientific and ethical uncertainty. Great concern has arisen across the …
Recent developments in genetics and medically-assisted reproduction: from research to clinical applications
Two leading European professional societies, the European Society of Human Genetics and
the European Society for Human Reproduction and Embryology, have worked together …
the European Society for Human Reproduction and Embryology, have worked together …
Principles of and strategies for germline gene therapy
DP Wolf, PA Mitalipov, SM Mitalipov - Nature medicine, 2019 - nature.com
Monogenic disorders occur at a high frequency in human populations and are commonly
inherited through the germline. Unfortunately, once the mutation has been transmitted to a …
inherited through the germline. Unfortunately, once the mutation has been transmitted to a …
Human germline genome editing: On the nature of our reasons to genome edit
R Sparrow - The American Journal of Bioethics, 2022 - Taylor & Francis
Ever since the publication of Derek Parfit's Reasons and Persons, bioethicists have tended
to distinguish between two different ways in which reproductive technologies may have …
to distinguish between two different ways in which reproductive technologies may have …
Toward anticipatory governance of human genome editing: A critical review of scholarly governance discourse
The rapid development of human genome editing (HGE) techniques evokes an urgent need
for forward-looking deliberation regarding the aims, processes, and governance of research …
for forward-looking deliberation regarding the aims, processes, and governance of research …
Yesterday's child: How gene editing for enhancement will produce obsolescence—and why it matters
R Sparrow - The American Journal of Bioethics, 2019 - Taylor & Francis
Despite the advent of CRISPR, safe and effective gene editing for human enhancement
remains well beyond our current technological capabilities. For the discussion about …
remains well beyond our current technological capabilities. For the discussion about …