Novel indole–chalcone derivative-ligated platinum (IV) prodrugs attenuate cisplatin resistance in lung cancer through ROS/ER stress and mitochondrial dysfunction
Z Liu, M Wang, R Huang, T Hu, Y Jing… - Journal of Medicinal …, 2023 - ACS Publications
Developing multifunctional platinum (IV) prodrugs via integrating bioactive pharmacophores
into one entity is an attractive strategy to ameliorate the defects of platinum (II) drugs. Herein …
into one entity is an attractive strategy to ameliorate the defects of platinum (II) drugs. Herein …
Novel NF-κB Inhibitor-Conjugated Pt (IV) Prodrug to Enable Cancer Therapy through ROS/ER Stress and Mitochondrial Dysfunction and Overcome Multidrug …
M Wang, G Li, G Jiang, J Cai, Z Liu… - Journal of Medicinal …, 2024 - ACS Publications
Although cisplatin has been widely used for clinical purposes, its application is limited due to
its obvious side effects. To mitigate the defects of cisplatin, here, six “multitarget prodrugs” …
its obvious side effects. To mitigate the defects of cisplatin, here, six “multitarget prodrugs” …
Glycyrrhetinic Acid as a Hepatocyte Targeting Ligand-Functionalized Platinum (IV) Complexes for Hepatocellular Carcinoma Therapy and Overcoming Multidrug …
X Huang, G Li, H Li, W Zhong, G Jiang… - Journal of Medicinal …, 2024 - ACS Publications
Promising targeted therapy options to overcome drug resistance and side effects caused by
platinum (II) drugs for treatment in hepatocellular carcinoma are urgently needed. Herein, six …
platinum (II) drugs for treatment in hepatocellular carcinoma are urgently needed. Herein, six …
Platinum (IV)-based prodrugs as an alternative to Pt (II)-based drugs: synthesis and biological action
DV Spector, AA Bubley, EK Beloglazkina… - Uspehi …, 2023 - journals.rcsi.science
The chemotherapy with cisplatin and its analogues widely used in medical practice is
associated with undesirable side effects caused by non-selective ligand exchange and …
associated with undesirable side effects caused by non-selective ligand exchange and …