Skeletal muscle extracellular matrix–what do we know about its composition, regulation, and physiological roles? A narrative review

R Csapo, M Gumpenberger, B Wessner - Frontiers in physiology, 2020 - frontiersin.org
Skeletal muscle represents the largest body-composition component in humans. In addition
to its primary function in the maintenance of upright posture and the production of …

Tissue engineering for clean meat production

T Ben-Arye, S Levenberg - Frontiers in Sustainable Food Systems, 2019 - frontiersin.org
Increasing public awareness of foodborne illnesses, factory farming, and the ecological
footprint of the meat industry, has generated the need for animal-free meat alternatives. In …

The central role of muscle stem cells in regenerative failure with aging

HM Blau, BD Cosgrove, ATV Ho - Nature medicine, 2015 - nature.com
Skeletal muscle mass, function, and repair capacity all progressively decline with aging,
restricting mobility, voluntary function, and quality of life. Skeletal muscle repair is facilitated …

Muscle tissue engineering in fibrous gelatin: implications for meat analogs

LA MacQueen, CG Alver, CO Chantre, S Ahn… - npj Science of …, 2019 - nature.com
Bioprocessing applications that derive meat products from animal cell cultures require food-
safe culture substrates that support volumetric expansion and maturation of adherent muscle …

Myostatin and its regulation: a comprehensive review of myostatin inhibiting strategies

MH Baig, K Ahmad, JS Moon, SY Park… - Frontiers in …, 2022 - frontiersin.org
Myostatin (MSTN) is a well-reported negative regulator of muscle growth and a member of
the transforming growth factor (TGF) family. MSTN has important functions in skeletal muscle …

Designing regenerative biomaterial therapies for the clinic

ET Pashuck, MM Stevens - Science translational medicine, 2012 - science.org
The ability to regenerate damaged tissue is one of the great challenges in biomaterials and
medicine. Successful treatments will require advances in areas ranging from basic cell …

A review of recent advances in natural polymer-based scaffolds for musculoskeletal tissue engineering

J Fan, K Abedi-Dorcheh, A Sadat Vaziri… - Polymers, 2022 - mdpi.com
The musculoskeletal (MS) system consists of bone, cartilage, tendon, ligament, and skeletal
muscle, which forms the basic framework of the human body. This system plays a vital role in …

Extracellular matrix regulation in the muscle satellite cell niche

K Thomas, AJ Engler, GA Meyer - Connective tissue research, 2015 - Taylor & Francis
Increasing evidence points to extracellular matrix (ECM) components playing integral roles
in regulating the muscle satellite cell (SC) niche. Even small alterations to the niche ECM …

Decellularized skeletal muscle: A versatile biomaterial in tissue engineering and regenerative medicine

C Philips, L Terrie, L Thorrez - Biomaterials, 2022 - Elsevier
A wide range of synthetic and natural biomaterials is available for skeletal muscle tissue
engineering. One class of natural biomaterials consists of the extracellular matrix (ECM) …

Tissue-engineered skeletal muscle models to study muscle function, plasticity, and disease

A Khodabukus - Frontiers in Physiology, 2021 - frontiersin.org
Skeletal muscle possesses remarkable plasticity that permits functional adaptations to a
wide range of signals such as motor input, exercise, and disease. Small animal models have …