Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

In recent years, the biological role of changes in physical factors in carcinogenesis and
progression has attracted increasing attention. Matrix stiffness, also known as ECM stress, is …

Mechanotransduction is a fundamental ability that allows living organisms to receive and
respond to physical signals from both the external and internal environments. The …

Mechanotransduction couples mechanical stimulation with ion flux, which is critical for
normal biological processes involved in neuronal cell development, pain sensation, and red …

Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Most cancer cells are exposed to altered extracellular environments, such as an increase in
extracellular matrix (ECM) stiffness and soluble signals consisting of growth factors and …

Many ion channels have been described as mechanosensitive according to various criteria.
Most broadly defined, an ion channel is called mechanosensitive if its activity is controlled by …

Background Despite integrin being highlighted as a stiffness‐sensor molecule in matrix
stiffness‐driven angiogenesis, other stiffness‐sensor molecules and their mechanosensory …

Piezo1 is a member of the mechanosensitive piezo ion channel family, which transduces
various mechanical stimulations into electrochemical signals. Piezo1 is closely implicated in …