Macrophages are present in many mechanically active tissues and are often subjected to
varying degrees of mechanical stimulation. Macrophages play a crucial role in resisting …

This study sheds light on a ground-breaking biochemical mechanotransduction pathway
and reveals how Piezo1 channels orchestrate cell migration. We observed an increased cell …

Environmental temperature and cellular mechanical force are the inherent factors that
participate in various biological processes and regulate cancer progress, which have been …

PIEZO1, a mechanosensitive ion channel protein, has been identified in the correlation
between several cancers. However, the systematic pancancer study of PIEZO1 still lacks …

As a transcriptional factor, the Forkhead box (FOX) gene family is closely connected with
apoptosis, proliferation, and other cellular processes. FOXD2, as one descendant of the FOX …

As a pathway that plays a role in nutrient absorption, anabolic response, cell growth and
survival, the important role of AKT/mTOR in tumorigenesis has also come to light. For cancer …

In the last three decades, a growing number of studies have implicated ion channels in all
essential processes of prostate carcinogenesis, including cell proliferation, apoptosis …

Background: Thyroid eye disease (TED) is characterized by orbital inflammation and
complicated by extraocular muscle fibrosis. Treatment with rapamycin/sirolimus has been …

The sodium channel epithelial 1 subunit gamma (SCNN1G) is mainly responsible for
sodium entry and absorption. The dysfunction of SCNN1G has been widely studied in …

Multiple myeloma (MM) is a highly invasive and incurable plasma cell malignant disease
with frequent recurrence. DCZ0801 is a natural compound synthesized from osalmide and …