Targeting sigma receptors for the treatment of neurodegenerative and neurodevelopmental disorders
DS Malar, P Thitilertdecha, KS Ruckvongacheep… - CNS drugs, 2023 - Springer
The sigma-1 receptor is a 223 amino acid-long protein with a recently identified structure.
The sigma-2 receptor is a genetically unrelated protein with a similarly shaped binding …
The sigma-2 receptor is a genetically unrelated protein with a similarly shaped binding …
Effect and mechanism of acupuncture on Alzheimer's disease: A review
L Wu, Y Dong, C Zhu, Y Chen - Frontiers in Aging Neuroscience, 2023 - frontiersin.org
With the development trend of an aging society, Alzheimer's disease (AD) has become an
urgent problem in the field of medicine worldwide. Cognitive impairment in AD patients …
urgent problem in the field of medicine worldwide. Cognitive impairment in AD patients …
Pre/postnatal taurine supplementation improves neurodevelopment and brain function in mice offspring: A persistent developmental study from puberty to maturity
MM Ommati, H Rezaei, RM Socorro, W Tian, J Zhao… - Life Sciences, 2024 - Elsevier
Taurine (TAU) is a sulfur-containing amino acid abundantly found in the human body.
Endogenously, TAU is synthesized from cysteine in the liver. However, newborns rely …
Endogenously, TAU is synthesized from cysteine in the liver. However, newborns rely …
Fluvoxamine Exerts Sigma-1R to Rescue Autophagy via Pom121-Mediated Nucleocytoplasmic Transport of TFEB
CY Lin, HE Wu, EFJ Weng, HC Wu, TP Su… - Molecular …, 2024 - Springer
Expansion of the GGGGCC-RNA repeat is a known cause of amyotrophic lateral sclerosis
(ALS) and frontotemporal dementia (FTD), which currently have no cure. Recent studies …
(ALS) and frontotemporal dementia (FTD), which currently have no cure. Recent studies …
Nuclear pore dysfunction and disease: a complex opportunity
CM Fare, JD Rothstein - Nucleus, 2024 - Taylor & Francis
The separation of genetic material from bulk cytoplasm has enabled the evolution of
increasingly complex organisms, allowing for the development of sophisticated forms of life …
increasingly complex organisms, allowing for the development of sophisticated forms of life …
Parapyruvate Induces Neurodegeneration in C57BL/6JNarl Mice via Inhibition of the α-Ketoglutarate Dehydrogenase Complex
I Lee, TY Song, CL Chen, JJ Yang, NC Yang - ACS omega, 2024 - ACS Publications
Parapyruvate is a substance commonly found in commercial dietary supplements of calcium
pyruvate (DSCP) that inhibits the α-ketoglutarate dehydrogenase complex (KGDHC) and …
pyruvate (DSCP) that inhibits the α-ketoglutarate dehydrogenase complex (KGDHC) and …
Rotating magnetic field improved cognitive and memory impairments in a sporadic ad model of mice by regulating microglial polarization
Neuroinflammation, triggered by aberrantly activated microglia, is widely recognized as a
key contributor to the initiation and progression of Alzheimer's disease (AD). Microglial …
key contributor to the initiation and progression of Alzheimer's disease (AD). Microglial …
Effects of Tanshinone IIA on Cognitive Impairment in Alzheimer's Disease Rats Via Oxidative Stress, Inflammatory Responses and Apoptosis
W Ren, X Li, T Wang, Y Liu, X Dai… - Pharmacognosy …, 2024 - journals.sagepub.com
Background The rationale for the pathogenesis of Alzheimer's disease (AD) is the
production of amyloid-beta (Aβ) and its resultant toxic effects. Purpose In this work, rats with …
production of amyloid-beta (Aβ) and its resultant toxic effects. Purpose In this work, rats with …
Fluvoxamine restores TFEB-mediated autophagy through sigma-1R-controlled POM121 expression
Expansion of the GGGGCC-RNA repeat is a known cause of amyotrophic lateral sclerosis
(ALS) and frontotemporal dementia (FTD), two conditions that currently have no cure …
(ALS) and frontotemporal dementia (FTD), two conditions that currently have no cure …