In vitro and animal studies have demonstrated that the effect of angiotensin II (Ang II) on
aldosterone is mediated through the Ang II type 1 receptor. However, it has been difficult to …

The objective of the present study was to determine the effects of early long-term
monotherapy with the angiotensin II AT1-receptor antagonist valsartan on the progression of …

Objective To describe a new class of antihypertensive agents, the angiotensin II receptor
antagonists, with emphasis on the prototype losartan. Pharmacokinetic data and clinical …

Background To investigate the interactive effect of plasma irbesartan concentration and
angiotensin II type 1 receptor (AGT1R) gene polymorphisms on blood pressure (BP) …

This study compared the efficacy and tolerability of two dose-titrated regimens of irbesartan,
an angiotensin II receptor antagonist selective for the AT 1 subtype, vs placebo in …

Abstract Irbesartan (SR 47436, BMS 186295) is an imidazole derivative that specifically
binds to the angiotensin type 1 receptor. The purpose of this study was to assess the …

Angiotensin-converting enzyme (ACE) inhibitors have proven an effective means to control
hypertension and manage cardiac hypertrophy. It is presently unknown if newer specific …

In 10 healthy normotensive volunteers on a normal sodium diet, we evaluated the renal
effects of a single oral dose of 50 mg of irbesartan (SR 47436, BMS 186295), an angiotensin …

Blockage of the renin-angiotensin system (RAS) is now recognized as an effective approach
to the treatment of hypertension and congestive heart failure. Today, it is possible to …

The primary objective of this study was to assess the effect of hydrochlorothiazide on the
pharmacokinetics of irbesartan in patients with mild-to-moderate hypertension. In addition …