In 10 healthy normotensive volunteers on a normal sodium diet, we evaluated the renal
effects of a single oral dose of 50 mg of irbesartan (SR 47436, BMS 186295), an angiotensin …

Abstract Irbesartan (SR 47436, BMS 186295) is an imidazole derivative that specifically
binds to the angiotensin type 1 receptor. The purpose of this study was to assess the …

Blockage of the renin-angiotensin system (RAS) is now recognized as an effective approach
to the treatment of hypertension and congestive heart failure. Today, it is possible to …

The primary objective of this study was to assess the effect of hydrochlorothiazide on the
pharmacokinetics of irbesartan in patients with mild-to-moderate hypertension. In addition …

Background: The pharmacodynamics (plasma angiotensin II [AII], plasma renin activity
[PRA], renal function, blood pressure [BP], urinary excretion of major metabolites of pros …

目的: 研究伊贝沙坦及苯那普利对中国高血压病患者肾素-醛固酮系统(RAS) 的影响. 方法:
轻中度高血压患者61 例, 停用各种抗高血压药一周后, 给予普通饮食及安慰剂两周 …

Inhibition of the angiotensin-converting enzyme (ACE) in the setting of chronic left ventricular
(LV) dysfunction has been demonstrated to have beneficial effects on survival and …

目的: 考察伊贝沙坦脉冲控释微丸的制备工艺. 方法: 采用流化床工艺, 将伊贝沙坦原料黏附在
空白丸芯上, 制成含药微丸; 以低取代羟丙基纤维素为包溶胀层材料, 乙基纤维素水分散体为包控 …

Nonenzymatic cardiac activities of renin are well described during the last years and
contribute either to cardiac‐specific effects of the renin‐angiotensin‐aldosterone‐system …

Background: AT1 angiotensin II (AT1 Ang II) receptor activation has been shown to cause
increased vascular resistance in the systemic (SVR), pulmonary (PVR), and coronary …