Mechanisms offsetting the beneficial effects of antihypertensive drugs: a problem increasingly considered but incompletely understood
TJM Cleophas - Clinical research and regulatory affairs, 1998 - Taylor & Francis
Background: In clinical practice it is far from uncommon that antihypertensive drugs fail to
meet their expectations. This is mainly due to mechanisms counteracting their …
meet their expectations. This is mainly due to mechanisms counteracting their …
Effect of Angiotensin receptor blockade on Plasma Osmolality and Neurohumoral Responses to High Environmental Temperature in Rats Fed a High Salt Diet
Plasma osmolality (pOsmol) and neurohumoral signals play important roles in the
pathophysiology of cardiovascular diseases. Our study investigated the effect of high …
pathophysiology of cardiovascular diseases. Our study investigated the effect of high …
The pharmacologic profile of 606A, a novel angiotensin II receptor antagonist
Y Hashimoto, Y Harada, H Narita, K Naito… - Journal of …, 1997 - journals.lww.com
The pharmacologic profile of a novel angiotensin I (AT 1) receptor antagonist 606A was
studied in various in vitro and in vivo preparations. The 606A showed a high affinity to AT 1 …
studied in various in vitro and in vivo preparations. The 606A showed a high affinity to AT 1 …
Angiotensin II receptor antagonists-antihypertensive agents
M Burnier, HR Brunner - Expert Opinion on Investigational Drugs, 1997 - Taylor & Francis
Blockade of the renin-angiotensin system (RAS) is now recognised as an effective approach
for the treatment of hypertension and congestive heart failure (CHF). Today, it is possible to …
for the treatment of hypertension and congestive heart failure (CHF). Today, it is possible to …
Irbesartan reduces creatinine clearance in type 1 diabetic children with renal hyperfunction: a randomized, double-blind, placebo-controlled trial
M Salcedo-Alejos, F Banda-Espinoza… - Nephrology Dialysis …, 2005 - academic.oup.com
Background. Previous studies in type 2 diabetes have demonstrated the renoprotective
effect of AT1-receptor antagonist drugs, but data on type 1 diabetic (T1DM) children are …
effect of AT1-receptor antagonist drugs, but data on type 1 diabetic (T1DM) children are …
厄贝沙坦对原发性高血压患者血脂及血流动力学的影响
李翠芳， 高继平 - 华北煤炭医学院学报, 2003 - cqvip.com
① 目的探讨厄贝沙坦对原发性高血压患者血脂及血流动力学的影响. ② 方法检测42
例原发性高血压患者服用厄贝沙坦75~ 150mg/d 治疗8 周前后血压, 血脂及血流动力学参数的 …
例原发性高血压患者服用厄贝沙坦75~ 150mg/d 治疗8 周前后血压, 血脂及血流动力学参数的 …
血管紧张素Ⅱ 受体拮抗剂的临床应用概述
谢红 - 医学综述, 2002 - cqvip.com
血管紧张素Ⅱ (AngⅡ) 受体阻滞剂通过选择性阻断AngⅡ 受体的ATI 亚型, 抑制肾素-
血管紧张素系统而产生降压效应. 代表性药物氯沙坦, 缬沙坦和伊贝沙坦已经用于临床 …
血管紧张素系统而产生降压效应. 代表性药物氯沙坦, 缬沙坦和伊贝沙坦已经用于临床 …
Comparison of irbesartan vs felodipine in the regression after 1 year of left ventricular hypertrophy in hypertensive patients (The SILVER trial)
A Cohen, B Bregman, EA Rosei, B Williams… - Journal of human …, 1998 - nature.com
Abstract The SILVER (Study of Irbesartan in Left VEntricular hypertrophy Regression) trial is
designed to test the hypothesis that the newly developed angiontensin-II receptor …
designed to test the hypothesis that the newly developed angiontensin-II receptor …
Effects of food on the pharmacokinetics of irbesartan/hydrochlorothiazide combination tablet
NN Vachharajani, WC Shyu, DS Greene… - Clinical drug …, 1998 - Springer
Objective: The effects of food on the pharmacokinetics of an irbesartan/hydrochlorothiazide
combination tablet were assessed in 16 healthy young male volunteers. Methods: Each …
combination tablet were assessed in 16 healthy young male volunteers. Methods: Each …