Role of inflammation and oxidative stress in chemotherapy-induced neurotoxicity

P Gupta, TK Makkar, L Goel, M Pahuja - Immunologic Research, 2022 - Springer
Chemotherapeutic agents may adversely affect the nervous system, including the neural
precursor cells as well as the white matter. Although the mechanisms are not completely …

[HTML][HTML] MicroRNAs and xenobiotic toxicity: an overview

S Balasubramanian, K Gunasekaran, S Sasidharan… - Toxicology reports, 2020 - Elsevier
The advent of new technologies has paved the rise of various chemicals that are being
employed in industrial as well as consumer products. This leads to the accumulation of …

[HTML][HTML] Contactin 1: An important and emerging oncogenic protein promoting cancer progression and metastasis

Y Gu, T Li, A Kapoor, P Major, D Tang - Genes, 2020 - mdpi.com
Even with recent progress, cancer remains the second leading cause of death, outlining a
need to widen the current understanding on oncogenic factors. Accumulating evidence from …

[HTML][HTML] Bortezomib inhibits multiple myeloma cells by transactivating ATF3 to trigger miR-135a-5p-dependent apoptosis

X Lai, C Huang, X Nie, Q Chen, Y Tang, X Fu… - Frontiers in …, 2021 - frontiersin.org
Multiple myeloma (MM) is a malignant cancer with an increasing in incidence that can be
alleviated through bortezomib (BTZ) treatment. Activating transcription factor 3 (ATF3) plays …

[HTML][HTML] Hypomethylating chemotherapeutic agents as therapy for myelodysplastic syndromes and prevention of acute myeloid leukemia

VG Sorrentino, S Thota, EA Gonzalez, P Rameshwar… - Pharmaceuticals, 2021 - mdpi.com
Myelodysplastic Syndromes (MDSs) affect the elderly and can progress to Acute Myeloid
Leukemia (AML). Epigenetic alterations including DNA methylation and chromatin …

[HTML][HTML] Differential secretion of angiopoietic factors and expression of microRNA in umbilical cord blood from healthy appropriate-for-gestational-age preterm and …

D Gródecka-Szwajkiewicz, Z Ulańczyk… - International Journal of …, 2020 - mdpi.com
Objectives: Premature birth, defined as less than 37 weeks gestation, affects approximately
12% of all live births around the world. Advances in neonatal care have resulted in the …

MicroRNA-221-5p promotes ricin toxin-induced inflammation via PI3K/akt signaling pathway by targeting COL4a5

N Zhao, H Yu, Y Xi, M Dong, Y Wang, C Sun, J Zhang… - Toxicon, 2022 - Elsevier
Ricin toxin (RT) is one of the most lethal type II ribosome-inactivating proteins (RIP), and is
classified as a potential bioterror agent due to its severe cytotoxicity and high availability …

[HTML][HTML] miR-33b-3p Acts as a Tumor Suppressor by Targeting DOCK4 in Prostate Cancer

Y Mei, K Li, Z Zhang, M Li, H Yang, H Wang… - Frontiers in …, 2021 - frontiersin.org
Despite that androgen-deprivation therapy results in long-lasting responses, the disease
inevitably progresses to metastatic castration-resistant prostate cancer. In this study, we …

[HTML][HTML] Effect of bortezomib on global gene expression in PC12-derived nerve cells

K Łuczkowska, D Rogińska, Z Ulańczyk… - International Journal of …, 2020 - mdpi.com
Peripheral neuropathy is one of the main side-effects of novel therapeutics used in
oncohematological diseases, but the molecular basis underlying its development and …

[HTML][HTML] Vitamin D and K Supplementation Is Associated with Changes in the Methylation Profile of U266-Multiple Myeloma Cells, Influencing the Proliferative …

K Łuczkowska, P Kulig, B Baumert, B Machaliński - Nutrients, 2023 - mdpi.com
Multiple myeloma (MM) is a plasma cell malignancy that, despite recent advances in
therapy, continues to pose a major challenge to hematologists. Currently, different classes of …