Lipids and lipid derivatives for RNA delivery
Y Zhang, C Sun, C Wang, KE Jankovic… - Chemical reviews, 2021 - ACS Publications
RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …
diseases through various mechanisms including knockdown of pathological genes …
RNAi-based therapeutics and tumor targeted delivery in cancer
Over the past decade, non-coding RNA-based therapeutics have proven as a great potential
for the development of targeted therapies for cancer and other diseases. The discovery of …
for the development of targeted therapies for cancer and other diseases. The discovery of …
miRNA: a promising therapeutic target in cancer
microRNAs are small non-coding RNAs that regulate several genes post-transcriptionally by
complementarity pairing. Since discovery, they have been reported to be involved in a …
complementarity pairing. Since discovery, they have been reported to be involved in a …
Nanoparticle-based drug delivery in cancer therapy and its role in overcoming drug resistance
Y Yao, Y Zhou, L Liu, Y Xu, Q Chen, Y Wang… - Frontiers in molecular …, 2020 - frontiersin.org
Nanotechnology has been extensively studied and exploited for cancer treatment as
nanoparticles can play a significant role as a drug delivery system. Compared to …
nanoparticles can play a significant role as a drug delivery system. Compared to …
[HTML][HTML] Recent progress in drug delivery
Drug delivery systems (DDS) are defined as methods by which drugs are delivered to
desired tissues, organs, cells and subcellular organs for drug release and absorption …
desired tissues, organs, cells and subcellular organs for drug release and absorption …
The potential for microRNA therapeutics and clinical research
J Hanna, GS Hossain, J Kocerha - Frontiers in genetics, 2019 - frontiersin.org
As FDA-approved small RNA drugs start to enter clinical medicine, ongoing studies for the
microRNA (miRNA) class of small RNAs expand its preclinical and clinical research …
microRNA (miRNA) class of small RNAs expand its preclinical and clinical research …
Rational design of bisphosphonate lipid-like materials for mRNA delivery to the bone microenvironment
L Xue, N Gong, SJ Shepherd, X Xiong… - Journal of the …, 2022 - ACS Publications
The development of lipid nanoparticle (LNP) formulations for targeting the bone
microenvironment holds significant potential for nucleic acid therapeutic applications …
microenvironment holds significant potential for nucleic acid therapeutic applications …
Non-coding RNA networks in cancer
E Anastasiadou, LS Jacob, FJ Slack - Nature Reviews Cancer, 2018 - nature.com
Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the
past decade has altered our perception of ncRNAs from'junk'transcriptional products to …
past decade has altered our perception of ncRNAs from'junk'transcriptional products to …
MicroRNA delivery through nanoparticles
MicroRNAs (miRNAs) are attracting a growing interest in the scientific community due to
their central role in the etiology of major diseases. On the other hand, nanoparticle carriers …
their central role in the etiology of major diseases. On the other hand, nanoparticle carriers …
Circulating microRNAs in cancer: potential and challenge
M Cui, H Wang, X Yao, D Zhang, Y Xie, R Cui… - Frontiers in …, 2019 - frontiersin.org
MicroRNAs (miRNAs) are endogenous non-coding small RNA molecules that can be
secreted into the circulation and exist in remarkably stable forms. Like intercellular miRNAs …
secreted into the circulation and exist in remarkably stable forms. Like intercellular miRNAs …