Brief update on endocytosis of nanomedicines
The complexity of nanoscale interactions between biomaterials and cells has limited the
realization of the ultimate vision of nanotechnology in diagnostics and therapeutics. As such …
realization of the ultimate vision of nanotechnology in diagnostics and therapeutics. As such …
Recent advances in polymeric nanoparticle-encapsulated drugs against intracellular infections
A Sánchez, SP Mejía, J Orozco - Molecules, 2020 - mdpi.com
Polymeric nanocarriers (PNs) have demonstrated to be a promising alternative to treat
intracellular infections. They have outstanding performance in delivering antimicrobials …
intracellular infections. They have outstanding performance in delivering antimicrobials …
Membrane wrapping efficiency of elastic nanoparticles during endocytosis: size and shape matter
Using coarse-grained molecular dynamics simulations, we systematically investigate the
receptor-mediated endocytosis of elastic nanoparticles (NPs) with different sizes, ranging …
receptor-mediated endocytosis of elastic nanoparticles (NPs) with different sizes, ranging …
Targeting endothelial permeability in the EPR effect
The characteristics of the primary tumor blood vessels and the tumor microenvironment drive
the enhanced permeability and retention (EPR) effect, which confers an advantage towards …
the enhanced permeability and retention (EPR) effect, which confers an advantage towards …
Nanotechnology as a tool to overcome macromolecules delivery issues
Nanocarriers can deliver drugs to specific organs or cells, potentially bridging the gap
between a drug's function and its interaction with biological systems such as human …
between a drug's function and its interaction with biological systems such as human …
Systematic evaluation of transferrin-modified porous silicon nanoparticles for targeted delivery of doxorubicin to glioblastoma
There is a dire need to develop more effective therapeutics to combat brain cancer such as
glioblastoma multiforme (GBM). An ideal treatment is expected to target deliver …
glioblastoma multiforme (GBM). An ideal treatment is expected to target deliver …
Blood-brain barrier receptors and transporters: an insight on their function and how to exploit them through nanotechnology
Introduction: The blood-brain barrier (BBB) is a highly limiting barrier that prevents the brain
from contacting with several circulating molecules, including harmful agents. However …
from contacting with several circulating molecules, including harmful agents. However …
Rhombohedron and plate-like hematite (α-Fe2O3) nanoparticles: synthesis, structure, morphology, magnetic properties and potential biomedical applications for MRI
Hematite nanorhombohedrons and nanoplates have been prepared through a hydrothermal
synthesis process. The nanoplates possess width of 100 nm and thickness of 30 nm …
synthesis process. The nanoplates possess width of 100 nm and thickness of 30 nm …
Investigation of cellular uptake mechanism of functionalised gold nanoparticles into breast cancer using SERS
Gold nanoparticles (AuNPs) are widely used in various applications such as cancer imaging
and drug delivery. The functionalisation of AuNPs has been shown to affect their cellular …
and drug delivery. The functionalisation of AuNPs has been shown to affect their cellular …
Impacts of particle shapes on the oral delivery of drug nanocrystals: Mucus permeation, transepithelial transport and bioavailability
M Guo, M Wei, W Li, M Guo, C Guo, M Ma… - Journal of controlled …, 2019 - Elsevier
For drug nanocrystals (NCs), particle shapes can affect aqueous solubility, dissolution rate
and oral bioavailability. However, the effects of particle shapes on the transport of NCs …
and oral bioavailability. However, the effects of particle shapes on the transport of NCs …