[HTML][HTML] Intranasal drug delivery: opportunities and toxicologic challenges during drug development

LA Keller, O Merkel, A Popp - Drug delivery and translational research, 2022 - Springer
Over the past 10 years, the interest in intranasal drug delivery in pharmaceutical R&D has
increased. This review article summarises information on intranasal administration for local …

Progress in nasal drug delivery systems

F Laffleur, B Bauer - International Journal of Pharmaceutics, 2021 - Elsevier
Most of the available drugs are usually administered orally (eg in tablets or capsules) or by
parenteral injection in the case of substances being destroyed in the gastric environment or …

[HTML][HTML] Lipid-core nanoparticles: Classification, preparation methods, routes of administration and recent advances in cancer treatment

P Graván, A Aguilera-Garrido, JA Marchal… - Advances in Colloid and …, 2023 - Elsevier
Nanotechnological drug delivery platforms represent a new paradigm for cancer
therapeutics as they improve the pharmacokinetic profile and distribution of …

How nanoparticles open the paracellular route of biological barriers: mechanisms, applications, and prospects

J Wu, Z Zhu, W Liu, Y Zhang, Y Kang, J Liu, C Hu… - ACS …, 2022 - ACS Publications
Biological barriers are essential physiological protective systems and obstacles to drug
delivery. Nanoparticles (NPs) can access the paracellular route of biological barriers, either …

Ivermectin: an award-winning drug with expected antiviral activity against COVID-19

FR Formiga, R Leblanc, J de Souza Rebouças… - Journal of controlled …, 2021 - Elsevier
Ivermectin is an FDA-approved broad-spectrum antiparasitic agent with demonstrated
antiviral activity against a number of DNA and RNA viruses, including severe acute …

Polymeric nanoparticles for nasal drug delivery to the brain: relevance to Alzheimer's disease

N Rabiee, S Ahmadi, R Afshari, S Khalaji… - Advanced …, 2021 - Wiley Online Library
Currently, Alzheimer's disease (AD) accounts for more than half of all dementia cases.
Although genetics, age, and environmental factors affect the disease, the cause of AD is not …

[HTML][HTML] Oral inhalation for delivery of proteins and peptides to the lungs

E Fröhlich, S Salar-Behzadi - European Journal of Pharmaceutics and …, 2021 - Elsevier
Oral inhalation is the preferred route for delivery of small molecules to the lungs, because
high tissue levels can be achieved shortly after application. Biologics are mainly …

Exploring the impact of physicochemical properties of liposomal formulations on their in vivo fate

B Sheikholeslami, NW Lam, K Dua, M Haghi - Life Sciences, 2022 - Elsevier
Liposomes, vesicles composed of a phospholipid bilayer, are considered a remarkably
advanced drug delivery system due to their unique properties, including their …

[HTML][HTML] Using the intranasal route to administer drugs to treat neurological and psychiatric illnesses: rationale, successes, and future needs

A Lofts, F Abu-Hijleh, N Rigg, RK Mishra, T Hoare - CNS drugs, 2022 - Springer
While the intranasal administration of drugs to the brain has been gaining both research
attention and regulatory success over the past several years, key fundamental and …

[HTML][HTML] Self-assembly of amphiphilic compounds as a versatile tool for construction of nanoscale drug carriers

R Kashapov, G Gaynanova, D Gabdrakhmanov… - International Journal of …, 2020 - mdpi.com
This review focuses on synthetic and natural amphiphilic systems prepared from straight-
chain and macrocyclic compounds capable of self-assembly with the formation of nanoscale …