[HTML][HTML] Functionalized hydrogels as smart gene delivery systems to treat musculoskeletal disorders

M Enayati, W Liu, H Madry, RE Neisiany… - Advances in Colloid and …, 2024 - Elsevier
Despite critical advances in regenerative medicine, the generation of definitive, reliable
treatments for musculoskeletal diseases remains challenging. Gene therapy based on the …

[HTML][HTML] Microenvironment-responsive metal-phenolic network release platform with ROS scavenging, anti-pyroptosis, and ECM regeneration for intervertebral disc …

H Zhou, J He, R Liu, J Cheng, Y Yuan, W Mao, J Zhou… - Bioactive Materials, 2024 - Elsevier
Intervertebral disc degeneration (IVDD) can be caused by aging, injury, and genetic factors.
The pathological changes associated with IVDD include the excessive accumulation of …

A multifunctional hydrogel dressing with high tensile and adhesive strength for infected skin wound healing in joint regions

C Zhang, K Liu, Y He, R Chang, F Guan… - Journal of Materials …, 2023 - pubs.rsc.org
Most hydrogel dressings are designed for skin wounds in flat areas, and few are focused on
the joint skin regions which undergo frequent movement. The mismatch of mechanical …

A guanosine/konjac glucomannan supramolecular hydrogel with antioxidant, antibacterial and immunoregulatory properties for cutaneous wound treatment

W Zhang, H Chen, J Zhao, P Chai, G Ma, X Shi… - Carbohydrate …, 2024 - Elsevier
Developing naturally-derived wound dressing materials with intrinsic therapeutic effects is
desirable for the clinical applications. Recently, guanosine-based supramolecular G …

Engineering injectable hyaluronic acid-based adhesive hydrogels with anchored PRP to pattern the micro-environment to accelerate diabetic wound healing

W Duan, X Jin, Y Zhao, S Martin-Saldaña, S Li… - Carbohydrate …, 2024 - Elsevier
Diabetic wounds remain a global challenge due to disordered wound healing led by
inflammation, infection, oxidative stress, and delayed proliferation. Therefore, an ideal …

Validity of stem cell-loaded scaffolds to facilitate endometrial regeneration and restore fertility: a systematic review and meta-analysis

Q Huang, H Zheng, Q Shi, J Xu - Frontiers in Endocrinology, 2024 - frontiersin.org
Objective Various stem cell-loaded scaffolds have demonstrated promising endometrial
regeneration and fertility restoration. This study aimed to evaluate the efficacy of stem cell …

Effect of autologous bone marrow stem cells-scaffold transplantation on the ongoing pregnancy rate in intrauterine adhesion women: a randomized, controlled trial

H Zhu, T Li, P Xu, L Ding, X Zhu, B Wang… - Science China Life …, 2024 - Springer
Intrauterine adhesion is a major cause of female reproductive disorders. Although we and
others uncontrolled pilot studies showed that treatment with autologous bone marrow stem …

Injectable, degradable, and mechanically adaptive hydrogel induced by L-serine and allyl-functionalized chitosan with platelet-rich plasma for treating intrauterine …

H Lv, R Xu, X Xie, Q Liang, W Yuan, Y Xia, X Ao, S Tan… - Acta Biomaterialia, 2024 - Elsevier
The integration of barrier materials with pharmacological therapy is a promising strategy to
treat intrauterine adhesions (IUAs). However, most of these materials are surgically …

Photo-crosslinkable hyaluronic acid microgels with reactive oxygen species scavenging capacity for mesenchymal stem cell encapsulation

S Hao, C Tian, Y Bai, L Wu, L Hao, Y Kuang… - International Journal of …, 2023 - Elsevier
Mesenchymal stem cells (MSCs) have gained increasing attention in various biomedical
applications. However, conventional therapeutic approaches, such as direct intravenous …

Organism-Inspired Antioxidant Bioadhesive with Strong Sealing Ability to Prevent Epidural Adhesion

Y Gong, B Zhu, Y Chen, F Li, W Duan… - ACS …, 2024 - ACS Publications
Epidural adhesion or epidural fibrosis is the major reason for postoperative pain, which
remains a clinically challenging problem. Current physical barriers fail to provide a …