Recent advances in the understanding of molecular mechanisms of cartilage degeneration, synovitis and subchondral bone changes in osteoarthritis

Y Wei, L Bai - Connective tissue research, 2016 - Taylor & Francis
Osteoarthritis (OA), the most common form of degenerative joint disease, is linked to high
morbidity. It is predicted to be the single greatest cause of disability in the general population …

[HTML][HTML] Loss of sclerostin promotes osteoarthritis in mice via β-catenin-dependent and-independent Wnt pathways

W Bouaziz, T Funck-Brentano, H Lin, C Marty… - Arthritis research & …, 2015 - Springer
Abstract Introduction Sclerostin is a Wnt inhibitor produced by osteocytes that regulates
bone formation. Because bone tissue contributes to the development of osteoarthritis (OA) …

Neutrophil elastase induces inflammation and pain in mouse knee joints via activation of proteinase‐activated receptor‐2

MM Muley, AR Reid, B Botz, K Boelcskei… - British journal of …, 2016 - Wiley Online Library
Background and Purpose Neutrophil elastase plays a crucial role in arthritis. Here, its
potential in triggering joint inflammation and pain was assessed, and whether these effects …

MicroRNA‐15a‐5p regulates the development of osteoarthritis by targeting PTHrP in chondrocytes

Z Duan, P Huang, C Tu, Q Liu, S Li… - BioMed Research …, 2019 - Wiley Online Library
Background and Aims. A growing body of research has demonstrated that the degeneration
of chondrocytes is the primary cause of osteoarthritis (OA). Parathyroid hormone‐related …

[HTML][HTML] STAT3 speeds up progression of osteoarthritis through NF‑κB signaling pathway

F Wang, Z Guo, Y Yuan - Experimental and therapeutic …, 2020 - spandidos-publications.com
Osteoarthritis (OA) is the most common motor system disease in the elderly, with a high
incidence and a huge social and economic burden. Therefore, it is urgent to study its …

[HTML][HTML] Achyranthes bidentata extract protects chondrocytes functions through suppressing glycolysis and apoptosis via MAPK/AKT signaling axis

D Ma, Y Li, W Xiao, L Peng, L Wang… - American Journal of …, 2020 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is considered to be a joint-associated disorder and one of leading
reasons for disability, however, potential mechanism has never been clarified. The purpose …

CX3CR1 regulates osteoarthrosis chondrocyte proliferation and apoptosis via Wnt/β-catenin signaling

Y Sun, F Wang, X Sun, X Wang, L Zhang, Y Li - Biomedicine & …, 2017 - Elsevier
Objective The study was aimed to investigate the impact of CX3CR1 expression on the
proliferation and apoptosis of osteoarthrosis (OA) chondrocytes through Wnt/β-catenin …

[HTML][HTML] Relación entre obesidad, adipocitoquinas y osteoatrosis: Una revisión

YE Quenan, JH Osorio - Universidad y Salud, 2017 - scielo.org.co
Introducción: Algunas adipocitoquinas expresadas por osteoblastos, condrocitos y
sinoviocitos son responsables de la inflamación y degradación de la matriz extracelular en …

Ubiquitin-specific protease 49 attenuates IL-1β-induced rat primary chondrocyte apoptosis by facilitating Axin deubiquitination and subsequent Wnt/β-catenin …

L Yang, Z Wang, C Zou, Y Mi, H Tang, X Wu - Molecular and Cellular …, 2020 - Springer
Osteoarthritis (OA) is an age-related chronic joint degenerative disease. Interleukin 1 beta
(IL-1β) is considered a marker for the progression of OA. In this study, we found that …

[HTML][HTML] Mechanism of TRPA1 and TRPV4 participating in mechanical hyperalgesia of rat experimental knee osteoarthritis

X Runlin, W Peimin, Z Linrui, XU Bo… - Archives of …, 2017 - ncbi.nlm.nih.gov
Mechanism of TRPA1 and TRPV4 Participating in Mechanical Hyperalgesia of Rat Experimental
Knee Osteoarthritis - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …