Heterogeneity and plasticity of epithelial–mesenchymal transition (EMT) in cancer metastasis: Focusing on partial EMT and regulatory mechanisms

D Li, L Xia, P Huang, Z Wang, Q Guo, C Huang… - Cell …, 2023 - Wiley Online Library
Epithelial–mesenchymal transition (EMT) or mesenchymal–epithelial transition (MET) plays
critical roles in cancer metastasis. Recent studies, especially those based on single‐cell …

Dual and multi-targeted nanoparticles for site-specific brain drug delivery

Y Luo, H Yang, YF Zhou, B Hu - Journal of Controlled Release, 2020 - Elsevier
In recent years, nanomedicines have emerged as a promising method for central nervous
system drug delivery, enabling the drugs to overcome the blood-brain barrier and …

Single-cell transcriptomics revealed subtype-specific tumor immune microenvironments in human glioblastomas

Y Xiao, Z Wang, M Zhao, Y Deng, M Yang… - Frontiers in …, 2022 - frontiersin.org
Human glioblastoma (GBM), the most aggressive brain tumor, comprises six major subtypes
of malignant cells, giving rise to both inter-patient and intra-tumor heterogeneity. The …

Single-cell transcriptomics in medulloblastoma reveals tumor-initiating progenitors and oncogenic cascades during tumorigenesis and relapse

L Zhang, X He, X Liu, F Zhang, LF Huang, AS Potter… - Cancer cell, 2019 - cell.com
Progenitor heterogeneity and identities underlying tumor initiation and relapse in
medulloblastomas remain elusive. Utilizing single-cell transcriptomic analysis, we …

Histone modifications and their role in epigenetics of cancer

S Zaib, N Rana, I Khan - Current medicinal chemistry, 2022 - ingentaconnect.com
Epigenetic regulations play a crucial role in the expression of various genes that are
important in the normal cell function. Any alteration in these epigenetic mechanisms can …

Quantum dots: The cutting-edge nanotheranostics in brain cancer management

P Chakraborty, SS Das, A Dey, A Chakraborty… - Journal of Controlled …, 2022 - Elsevier
Quantum dots (QDs) are semiconductor nanocrystals possessing unique optoelectrical
properties in that they can emit light energy of specific tunable wavelengths when excited by …

Glioblastoma therapy: past, present and future

E Obrador, P Moreno-Murciano… - International journal of …, 2024 - mdpi.com
Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer.
Although great efforts have been made by clinicians and researchers, no significant …

Long non-coding RNA PAXIP1-AS1 facilitates cell invasion and angiogenesis of glioma by recruiting transcription factor ETS1 to upregulate KIF14 expression

H Xu, G Zhao, Y Zhang, H Jiang, W Wang… - Journal of Experimental …, 2019 - Springer
Background Gliomas are common life-threatening cancers, mainly due to their aggressive
nature and frequent invasiveness and long non-coding RNAs (lncRNAs) are emerging as …

Multidrug resistance in cancer cells: focus on a possible strategy plan to address colon carcinoma cells

C Karthika, R Sureshkumar, M Zehravi, R Akter, F Ali… - Life, 2022 - mdpi.com
Even though various treatment methods are available for cancer, the death curve is not
reducing. The diagnosis of cancer at the fourth stage and drug resistance are the leading …

Organoid models of glioblastoma to study brain tumor stem cells

R Azzarelli - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Glioblastoma represents an aggressive form of brain cancer characterized by poor
prognosis and a 5-year survival rate of only 3–7%. Despite remarkable advances in brain …