Heterogeneity and plasticity of epithelial–mesenchymal transition (EMT) in cancer metastasis: Focusing on partial EMT and regulatory mechanisms
D Li, L Xia, P Huang, Z Wang, Q Guo, C Huang… - Cell …, 2023 - Wiley Online Library
Epithelial–mesenchymal transition (EMT) or mesenchymal–epithelial transition (MET) plays
critical roles in cancer metastasis. Recent studies, especially those based on single‐cell …
critical roles in cancer metastasis. Recent studies, especially those based on single‐cell …
Dual and multi-targeted nanoparticles for site-specific brain drug delivery
Y Luo, H Yang, YF Zhou, B Hu - Journal of Controlled Release, 2020 - Elsevier
In recent years, nanomedicines have emerged as a promising method for central nervous
system drug delivery, enabling the drugs to overcome the blood-brain barrier and …
system drug delivery, enabling the drugs to overcome the blood-brain barrier and …
Single-cell transcriptomics revealed subtype-specific tumor immune microenvironments in human glioblastomas
Human glioblastoma (GBM), the most aggressive brain tumor, comprises six major subtypes
of malignant cells, giving rise to both inter-patient and intra-tumor heterogeneity. The …
of malignant cells, giving rise to both inter-patient and intra-tumor heterogeneity. The …
Single-cell transcriptomics in medulloblastoma reveals tumor-initiating progenitors and oncogenic cascades during tumorigenesis and relapse
Progenitor heterogeneity and identities underlying tumor initiation and relapse in
medulloblastomas remain elusive. Utilizing single-cell transcriptomic analysis, we …
medulloblastomas remain elusive. Utilizing single-cell transcriptomic analysis, we …
Histone modifications and their role in epigenetics of cancer
Epigenetic regulations play a crucial role in the expression of various genes that are
important in the normal cell function. Any alteration in these epigenetic mechanisms can …
important in the normal cell function. Any alteration in these epigenetic mechanisms can …
Quantum dots: The cutting-edge nanotheranostics in brain cancer management
Quantum dots (QDs) are semiconductor nanocrystals possessing unique optoelectrical
properties in that they can emit light energy of specific tunable wavelengths when excited by …
properties in that they can emit light energy of specific tunable wavelengths when excited by …
Glioblastoma therapy: past, present and future
E Obrador, P Moreno-Murciano… - International journal of …, 2024 - mdpi.com
Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer.
Although great efforts have been made by clinicians and researchers, no significant …
Although great efforts have been made by clinicians and researchers, no significant …
Long non-coding RNA PAXIP1-AS1 facilitates cell invasion and angiogenesis of glioma by recruiting transcription factor ETS1 to upregulate KIF14 expression
H Xu, G Zhao, Y Zhang, H Jiang, W Wang… - Journal of Experimental …, 2019 - Springer
Background Gliomas are common life-threatening cancers, mainly due to their aggressive
nature and frequent invasiveness and long non-coding RNAs (lncRNAs) are emerging as …
nature and frequent invasiveness and long non-coding RNAs (lncRNAs) are emerging as …
Multidrug resistance in cancer cells: focus on a possible strategy plan to address colon carcinoma cells
Even though various treatment methods are available for cancer, the death curve is not
reducing. The diagnosis of cancer at the fourth stage and drug resistance are the leading …
reducing. The diagnosis of cancer at the fourth stage and drug resistance are the leading …
Organoid models of glioblastoma to study brain tumor stem cells
R Azzarelli - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Glioblastoma represents an aggressive form of brain cancer characterized by poor
prognosis and a 5-year survival rate of only 3–7%. Despite remarkable advances in brain …
prognosis and a 5-year survival rate of only 3–7%. Despite remarkable advances in brain …