The Brugada syndrome is an inherited disorder associated with risk of ventricular fibrillation
and sudden cardiac death in a structurally normal heart. Diagnosis is based on a …

SCN5A gene encodes the pore-forming ion-conducting α-subunit of the cardiac sodium
channel (Nav1. 5), which is responsible for the initiation and propagation of action potentials …

Brugada syndrome (BrS) is an “inherited” condition characterized by predisposition to
syncope and cardiac arrest, predominantly during sleep. The prevalence is∼ 1: 2,000, and …

Inflammatory activation is increasingly recognized as a nonconventional risk factor for
arrhythmias, and experimental studies provided robust evidence that this association is …

The incidence and prevalence of cardiac diseases, which are the main cause of death
worldwide, are likely to increase because of population ageing. Prevailing theories about …

Cardiac arrhythmias are associated with high morbidity and mortality. 1 Specifically,
malignant arrhythmias are a recognized leading cause of sudden cardiac death (SCD) in the …

Brugada syndrome (BS) is an inherited disease characterized by a coved-type ST-segment
elevation in the right precordial leads and increased risk of sudden cardiac death (SCD), in …

Summary Background Brugada syndrome (BrS) is a cardiac channelopathy that can result in
sudden cardiac death (SCD). SCN5A is the most frequent gene linked to BrS, but the …

Background Brugada syndrome is a major cause of sudden cardiac death in young people
and has distinctive electrocardiographic (ECG) features. We aimed to develop a deep …

The voltage-gated sodium channel 1.5 (Nav1. 5), encoded by the SCN5A gene, is
responsible for the rising phase of the action potential of cardiomyocytes. The sodium …