Polybrominated diphenyl ethers (PBDEs) can be metabolically converted to their
hydroxylated metabolites (OH-PBDEs). The estrogenic effects of PBDEs may be mediated …

Increased exposure of birds to endocrine disrupting compounds has resulted in
developmental and reproductive dysfunctions. We have recently identified the flame …

Organophosphate flame retardants (OPFRs) have been reported to induce cytotoxicity in a
structure-dependent manner. The toxic effects may be due to the damage of biomembrane …

We investigated the Baikal seal (Pusa sibirica) peroxisome proliferator-activated receptor α
(bsPPARα) transactivation potencies of polybrominated diphenyl ethers (PBDEs) using an in …

溴系阻燃剂(brominated flame retardants, BFRs) 作为生产和使用量巨大的有机阻燃剂,
在环境介质和生物体内被广泛检出. BFRs 及其代谢产物会对生物体造成神经毒性, 遗传毒性 …

Ultra performance liquid chromatography (UPLC) provides improved resolution, speed and
sensitivity compared to conventional high performance liquid chromatography (HPLC). In …

For a better understanding of species-specific relative effect potencies (REPs), responses of
dioxin-like compounds (DLCs) were assessed. REPs were calculated using chemical …

Polybrominated diphenyl ethers (PBDEs) have become ubiquitous contaminations due to
their use as flame retardants. The structural similarity of PBDE to some dioxin-like …

PBDEs and their metabolites are of concern due to their increasing concentrations in the
environment and their toxic effects. Knowledge about the toxicological mechanisms of …

A structural similarity tool was developed and aimed to search for environmentally persistent
drugs. The basis for the tool was a selection of so-called anchor molecules and a …