An official American Thoracic Society clinical practice guideline: classification, evaluation, and management of childhood interstitial lung disease in infancy

G Kurland, RR Deterding, JS Hagood… - American journal of …, 2013 - atsjournals.org
Background: There is growing recognition and understanding of the entities that cause
interstitial lung disease (ILD) in infants. These entities are distinct from those that cause ILD …

Immunoregulatory functions of surfactant proteins

JR Wright - Nature Reviews Immunology, 2005 - nature.com
Because the lungs function as the body's gas-exchange organ, they are inevitably exposed
to air that is contaminated with pathogens, allergens and pollutants. Host-defence …

Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples

L Leng, R Cao, J Ma, D Mou, Y Zhu, W Li, L Lv… - … and Targeted Therapy, 2020 - nature.com
The COVID-19 pandemic has emerged as a global health emergency due to its association
with severe pneumonia and relative high mortality. However, the molecular characteristics …

[HTML][HTML] Structure-function relationships in pulmonary surfactant membranes: from biophysics to therapy

E Lopez-Rodriguez, J Pérez-Gil - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
Pulmonary surfactant is an essential lipid–protein complex to maintain an operative
respiratory surface at the mammalian lungs. It reduces surface tension at the alveolar air …

[HTML][HTML] Structure of pulmonary surfactant membranes and films: the role of proteins and lipid–protein interactions

J Pérez-Gil - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2008 - Elsevier
The pulmonary surfactant system constitutes an excellent example of how dynamic
membrane polymorphism governs some biological functions through specific lipid–lipid …

Pulmonary alveolar proteinosis in adults: pathophysiology and clinical approach

A Kumar, B Abdelmalak, Y Inoue… - The Lancet Respiratory …, 2018 - thelancet.com
Pulmonary alveolar proteinosis (PAP) is a diffuse lung disease that results from the
accumulation of lipoproteinaceous material in the alveoli and alveolar macrophages due to …

Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease

JA Whitsett, SE Wert, TE Weaver - Annual review of medicine, 2010 - annualreviews.org
The alveolar region of the lung creates an extensive epithelial surface that mediates the
transfer of oxygen and carbon dioxide required for respiration after birth. Maintenance of …

Surfactant phospholipid metabolism

M Agassandian, RK Mallampalli - … et Biophysica Acta (BBA)-Molecular and …, 2013 - Elsevier
Pulmonary surfactant is essential for life and is composed of a complex lipoprotein-like
mixture that lines the inner surface of the lung to prevent alveolar collapse at the end of …

Diseases of pulmonary surfactant homeostasis

JA Whitsett, SE Wert, TE Weaver - Annual Review of Pathology …, 2015 - annualreviews.org
Advances in physiology and biochemistry have provided fundamental insights into the role
of pulmonary surfactant in the pathogenesis and treatment of preterm infants with respiratory …

Pulmonary alveolar proteinosis

BC Trapnell, K Nakata, F Bonella, I Campo… - Nature Reviews …, 2019 - nature.com
Pulmonary alveolar proteinosis (PAP) is a syndrome characterized by the accumulation of
alveolar surfactant and dysfunction of alveolar macrophages. PAP results in progressive …