• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Background—Infective endocarditis is a potentially lethal disease that has undergone major
changes in both host and pathogen. The epidemiology of infective endocarditis has become …

LRRC4 is a novel relatively specific gene, which displays significant down-regulation in
primary brain tumor biopsies and has the potential to suppress brain tumor growth. In this …

Importance Methicillin-resistantStaphylococcus aureus (MRSA) bacteremia is associated
with mortality of more than 20%. Combining standard therapy with a β-lactam antibiotic has …

Importance Several management strategies may improve outcomes in patients
withStaphylococcus aureusbacteremia. Objectives To review evidence of management …

The content of these European Society of Cardiology (ESC) Guidelines has been published
for personal and educational use only. No commercial use is authorized. No part of the ESC …

Micrococcus, which, when limited in its extent and activity, causes acute suppurative
inflammation (phlegmon), produces, when more extensive and intense in its action on the …

Despite improvements in medical and surgical therapies, infective endocarditis is associated
with poor prognosis and remains a therapeutic challenge. Many factors affect the outcome of …

The distinction between bactericidal and bacteriostatic agents appears to be clear according
to the in vitro definition, but this only applies under strict laboratory conditions and is …

Background—Despite advances in medical, surgical, and critical care interventions, infective
endocarditis remains a disease that is associated with considerable morbidity and mortality …