Inflammatory reaction following a spinal cord injury (SCI) contributes substantially to
secondary effects, with both beneficial and devastating effects. This review summarizes the …

Spinal cord injury (SCI) is a major cause of disability, and at present, there is no universally
accepted treatment. The functional decline following SCI is contributed to both direct …

Genetically engineered mice are used extensively to examine molecular responses to spinal
cord injury (SCI). Inherent strain differences may confound behavioral outcomes; therefore …

Peptide amphiphile (PA) molecules that self-assemble in vivo into supramolecular
nanofibers were used as a therapy in a mouse model of spinal cord injury (SCI). Because …

Acute spinal cord injury (SCI) produces tissue damage that continues to evolve days and
weeks after the initial insult, with corresponding functional impairments. Reducing the extent …

Spinal contusion pathology in rats and mice is distinct. Cystic cavities form at the impact site
in rats while a dense connective tissue matrix occupies the injury site in mice. Because …

Neural stem cells (NSCs) from embryonic or fetal/adult tissue sources have shown
considerable promise in regenerative strategies for traumatic spinal cord injury (SCI) …

Yes-associated protein (YAP) transcriptional coactivator is negatively regulated by the Hippo
pathway and functions in controlling the size of multiple organs, such as liver during …

Abstract Aquaporin-4 (AQP4) is a water channel protein expressed in astrocytes throughout
the CNS. In brain, AQP4 facilitates water balance and glial scar formation, which are …

Traumatic spinal cord injuries (SCIs) affect millions of people worldwide; the majority of
whom are in the chronic phase of their injury. Unfortunately, most current treatments target …