Heart failure (HF) is a leading cause of morbidity and mortality in the United States. Despite
a number of important therapeutic advances for the treatment of symptomatic HF, 1 the …

Calcium (Ca2+) is a critical regulator of cardiac myocyte function. Principally, Ca2+ is the
link between the electrical signals that pervade the heart and contraction of the myocytes to …

Background: The mitochondrial calcium uniporter (mtCU) is an≈ 700-kD multisubunit
channel residing in the inner mitochondrial membrane required for mitochondrial Ca2+ …

The dysfunction of the blood circulation system typically induces acute or chronic ischemia
in limbs and vital organs, with high disability and mortality. While conventional tomographic …

Medical soft robotics constitutes a rapidly developing field in the treatment of cardiovascular
diseases, with a promising future for millions of patients suffering from heart failure …

Rhythmic increases in intracellular Ca2+ concentration underlie the contractile function of
the heart. These heart muscle-wide changes in intracellular Ca2+ are induced and …

Calcium ions are the major signaling ions in the cells. They regulate muscle contraction,
neurotransmitter secretion, cell growth and migration, and the activity of several proteins …

Left ventricular ejection time (LVET) is defined as the time interval from aortic valve opening
to aortic valve closure, and is the phase of systole during which the left ventricle ejects blood …

The clinical importance of heart failure with preserved ejection fraction (HFpEF) has recently
become apparent. HFpEF refers to heart failure (HF) symptoms with normal or near-normal …

Time-varying elastance models can simulate only the pressure and volume signals in the
heart chambers while the diagnosis of clinical cases and evaluation of different treatment …