The ubiquitin-proteasome system (UPS) is the major machinery mediating specific protein
turnover in eukaryotic cells. By ubiquitylating unwanted, damaged, or harmful proteins and …

Lung cancer constitutes a formidable menace to global health and well-being, as its
incidence and mortality rate escalate at an alarming pace. In recent years, research has …

EZH2 is a member of PcG and can induce the occurrence of cancer when it is highly
expressed. As an EZH2 inhibitor, Tazemetostat (EPZ6438) can inhibit the methylation …

Cisplatin nephrotoxicity is an etiological factor for acute kidney injury (AKI). MicroRNA
(miRNA) expression is dysregulated in cisplatin‐induced AKI (cAKI) although the underlying …

A wealth of evidence has emerged that there is an association between aging, senescence
and tumorigenesis. Senescence, a biological process by which cells cease to divide and …

Ethnopharmacological relevance Polygonatum sibiricum, commonly known as Siberian
Solomon's seal, is a traditional herb widely used in various traditional medical systems …

The scientific community has shown considerable interest in proteolysis-targeting chimeras
(PROTACs) in the last decade, indicating their remarkable potential as a means of achieving …

Lymphocyte-specific protein tyrosine kinase (LCK), a member of the Src family of tyrosine
kinases, is implicated in the pathogenesis of almost all types of leukemia via T cells …

Abstract Hexokinase 2 (HK2) is the rate-limiting enzyme in the first step of glycolysis,
catalyzing glucose to glucose-6-phosphate, and overexpressed in most cancer cells. HK2 …

Numerous studies have demonstrated that long non-coding RNAs (lncRNAs) play crucial
roles in tumor progression. This study aimed to identify lncRNAs associated with overall …