The Crc protein inhibits the production of polyhydroxyalkanoates in Pseudomonas putida under balanced carbon/nitrogen growth conditions

R La Rosa, F de la Peña, MA Prieto… - Environmental …, 2014 - Wiley Online Library
P seudomonas putida synthesizes polyhydroxyalkanoates (PHAs) as storage compounds.
PHA synthesis is more active when the carbon source is in excess and the nitrogen source …

Quantitative proteomics unravels that the post-transcriptional regulator Crc modulates the generation of vesicles and secreted virulence determinants of Pseudomonas …

JA Reales-Calderón, F Corona, L Monteoliva, C Gil… - Journal of …, 2015 - Elsevier
Recent research indicates that the post-transcriptional regulator Crc modulates susceptibility
to antibiotics and virulence in Pseudomonas aeruginosa. Several P. aeruginosa virulence …

Machine learning analysis of RB-TnSeq fitness data predicts functional gene modules in Pseudomonas putida KT2440

AJ Borchert, AC Bleem, HG Lim, K Rychel, KD Dooley… - Msystems, 2024 - Am Soc Microbiol
There is growing interest in engineering Pseudomonas putida KT2440 as a microbial
chassis for the conversion of renewable and waste-based feedstocks, and metabolic …

The β-ketoadipate pathway of Acinetobacter baylyi undergoes carbon catabolite repression, cross-regulation and vertical regulation, and is affected by Crc

FS Bleichrodt, R Fischer, UC Gerischer - Microbiology, 2010 - microbiologyresearch.org
The degradation of many structurally diverse aromatic compounds in Acinetobacter baylyi is
accomplished by the β-ketoadipate pathway. In addition to specific induction of expression …

Small RNAs regulate primary and secondary metabolism in Gram‐negative bacteria

M Bobrovskyy, CK Vanderpool… - Metabolism and …, 2015 - Wiley Online Library
A diverse palette of novel small regulatory RNAs (sRNAs) has been identified in bacteria in
recent years, and many play important roles in regulating gene expression and adaptation to …

Effect of Crc and Hfq proteins on the transcription, processing, and stability of the Pseudomonas putida CrcZ sRNA

S Hernández-Arranz, D Sánchez-Hevia, F Rojo… - Rna, 2016 - rnajournal.cshlp.org
In Pseudomonas putida, the Hfq and Crc proteins regulate the expression of many genes in
response to nutritional and environmental cues, by binding to mRNAs that bear specific …

Optimal bioprocess design through a gene regulatory network–Growth kinetic hybrid model: Towards replacing Monod kinetics

A Tsipa, M Koutinas, C Usaku, A Mantalaris - Metabolic engineering, 2018 - Elsevier
Currently, design and optimisation of biotechnological bioprocesses is performed either
through exhaustive experimentation and/or with the use of empirical, unstructured growth …

The antibiotic resistome: challenge and opportunity for therapeutic intervention

JL Martínez - Future medicinal chemistry, 2012 - Future Science
Despite the relevance of infectious disease as main causes of human morbidity and
mortality, the development of new antibacterials is not among the highest priorities for …

[HTML][HTML] Computational prediction of the Crc regulon identifies genus-wide and species-specific targets of catabolite repression control in Pseudomonas bacteria

P Browne, M Barret, F O'Gara, JP Morrissey - BMC microbiology, 2010 - Springer
Background Catabolite repression control (CRC) is an important global control system in
Pseudomonas that fine tunes metabolism in order optimise growth and metabolism in a …

Role of Acinetobacter baylyi Crc in Catabolite Repression of Enzymes for Aromatic Compound Catabolism

T Zimmermann, T Sorg, SY Siehler… - Journal of …, 2009 - Am Soc Microbiol
Here, we describe for the first time the Crc (c atabolite r epression c ontrol) protein from the
soil bacterium Acinetobacter baylyi. Expression of A. baylyi crc varied according to the …