Microglial phagocytosis: a disease-associated process emerging from Alzheimer's disease genetics
Alzheimer's disease (AD) is a debilitating, chronic neurodegenerative disease. Genetic
studies involving genome-wide association studies (GWAS) and meta-analysis have …
studies involving genome-wide association studies (GWAS) and meta-analysis have …
Advancing cell therapy for neurodegenerative diseases
S Temple - Cell Stem Cell, 2023 - cell.com
Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …
[HTML][HTML] New insights into the genetic etiology of Alzheimer's disease and related dementias
Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
Cell type-specific inference of differential expression in spatial transcriptomics
A central problem in spatial transcriptomics is detecting differentially expressed (DE) genes
within cell types across tissue context. Challenges to learning DE include changing cell type …
within cell types across tissue context. Challenges to learning DE include changing cell type …
[HTML][HTML] Nanomedicine-based technologies and novel biomarkers for the diagnosis and treatment of Alzheimer's disease: from current to future challenges
Increasing life expectancy has led to an aging population, which has consequently
increased the prevalence of dementia. Alzheimer's disease (AD), the most common form of …
increased the prevalence of dementia. Alzheimer's disease (AD), the most common form of …
Genomics of Alzheimer's disease implicates the innate and adaptive immune systems
Alzheimer's disease (AD) is a chronic neurodegenerative disease characterised by cognitive
impairment, behavioural alteration, and functional decline. Over 130 AD-associated …
impairment, behavioural alteration, and functional decline. Over 130 AD-associated …
New insights on the genetic etiology of Alzheimer's and related dementia
C Bellenguez, F Küçükali, I Jansen, V Andrade… - MedRxiv, 2020 - medrxiv.org
Deciphering the genetic landscape of Alzheimer's disease (AD) is essential to define the
pathophysiological pathways involved and to successfully translate genomics to potential …
pathophysiological pathways involved and to successfully translate genomics to potential …
[HTML][HTML] Progranulin deficiency exacerbates spinal cord injury by promoting neuroinflammation and cell apoptosis in mice
C Wang, L Zhang, JDLC Ndong… - Journal of …, 2019 - Springer
Purpose Spinal cord injury (SCI) often results in significant and catastrophic dysfunction and
disability and imposes a huge economic burden on society. This study aimed to determine …
disability and imposes a huge economic burden on society. This study aimed to determine …
[HTML][HTML] Role of neuron and glia in Alzheimer's disease and associated vascular dysfunction
S Bandyopadhyay - Frontiers in aging neuroscience, 2021 - frontiersin.org
Amyloidogenicity and vascular dysfunction are the key players in the pathogenesis of
Alzheimer's disease (AD), involving dysregulated cellular interactions. An intricate balance …
Alzheimer's disease (AD), involving dysregulated cellular interactions. An intricate balance …
[HTML][HTML] Peroxisomal defects in microglial cells induce a disease-associated microglial signature
Q Raas, A Tawbeh, M Tahri-Joutey… - Frontiers in Molecular …, 2023 - frontiersin.org
Microglial cells ensure essential roles in brain homeostasis. In pathological condition,
microglia adopt a common signature, called disease-associated microglial (DAM) signature …
microglia adopt a common signature, called disease-associated microglial (DAM) signature …