Comorbid proteinopathies are observed in many neurodegenerative disorders including
Alzheimer's disease (AD), increase with age, and influence clinical outcomes, yet the …

Experimental studies of neuroinflammation in Alzheimer's disease (AD) have mostly
investigated microglia, the brain-resident macrophages. This review focused on human …

Background Alzheimer's disease (AD) neuropathology reveals progressive microstructural
alterations of cortical architecture. Recent studies reported intriguing biphasic trajectories of …

Neuronal ceroid lipofuscinosis (NCL) is one of the most prevalent neurodegenerative
disorders of early life, Parkinson's disease (PD) is the most common neurodegenerative …

Introduction Progranulin (GRN) mutations occur in frontotemporal lobar degeneration
(FTLD) and in Alzheimer's disease (AD), often with TDP‐43 pathology. Methods We …

Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal lobar
degeneration (FTLD). PGRN polymorphisms are associated with Alzheimer's disease …

Alzheimer's disease (AD) is ranked as the third-most expensive illness and sixth leading
cause of mortality. It is associated with the deposition of extracellular amyloid-β (Aβ) in …

Immuno-neurology is an emerging therapeutic strategy for dementia and neurodegeneration
designed to address immune surveillance failure in the brain. Microglia, as central nervous …

Progranulin (PGRN), a growth factor, is abundantly expressed in a broad range of tissues
and cell types with pleiotropic functions including inflammation, neurodegeneration, and …

Frontotemporal dementia (FTD) is a debilitating neurodegenerative disorder with currently
no disease-modifying treatment options available. Mutations in GRN are one of the most …