Golden Retriever dogs with a frameshift variant in CLN5 (c. 934_935delAG) suffer from a
progressive neurodegenerative disorder analogous to the CLN5 form of neuronal ceroid …

Alzheimer's disease (AD) is a complex neurodegenerative disorder with a multifactorial
etiology, including genetic factors that play a significant role in disease susceptibility …

Cerebrospinal fluid (CSF) progranulin (PGRN) is related to various neurodegeneration
diseases. And sleep problems can cause abnormality in protein metabolism in vivo. We aim …

Transcriptional dysregulation is a hallmark of numerous neurological disorders, offering
targetable pathways with the potential to alter disease progression substantially. This …

Neuroimmunology is emerging as a pivotal field, shedding light on the intricate dialogues
between the central nervous system (CNS) and the immune system. This exploration is …

Lysosomal dysfunction is linked to several neurodegenerative diseases. Recent GWAS
studies have implicated genes in endo-lysosomal pathways as risk factors for developing …

Type 1 diabetes mellitus (T1DM) comprise the most common forms of autoimmune disease.
The aim of this investigation was to apply a bioinformatics approach to reveal related …

Frontotemporal lobar degeneration (FTLD) is a common form of early-onset dementia
presenting with a complex gene and pathological architecture. Impairment in several …

Granulins (GRNs) are small, cysteine-rich modules produced from the proteolytic cleavage
of the precursor protein called progranulin (PGRN). GRNs are present in the form of seven …

Abstract 16 Spatial transcriptomics enables spatially resolved gene expression
measurements at near 17 single-cell resolution. There is a pressing need for computational …