The tumor microenvironment (TME) is a complex and ever-changing “rogue organ”
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …

The human epidermal growth factor receptor (EGFR) family consists of four members that
belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated …

The advent of digital pathology provides us with the challenging opportunity to automatically
analyze whole slides of diseased tissue in order to derive quantitative profiles that can be …

Cell migration through 3D tissue depends on a physicochemical balance between cell
deformability and physical tissue constraints. Migration rates are further governed by the …

ERK1 and ERK2 are related protein-serine/threonine kinases that participate in the Ras-Raf-
MEK-ERK signal transduction cascade. This cascade participates in the regulation of a large …

YAP/TAZ is a master regulator of mechanotransduction whose functions rely on
translocation from the cytoplasm to the nucleus in response to diverse physical cues …

Deep learning (DL) has achieved state-of-the-art performance in many digital pathology
analysis tasks. Traditional methods usually require hand-crafted domain-specific features …

Although at the genetic level cancer is caused by diverse mutations, epigenetic
modifications are characteristic of all cancers, from apparently normal precursor tissue to …

Background: For more than a century, diagnostic pathologists have used morphologic
abnormalities of the nucleus as essential diagnostic features to distinguish benign from …

Lung cancer is a malignant lung tumor with various histological variants that arise from
different cell types, such as bronchial epithelium, bronchioles, alveoli, or bronchial mucous …