Pulmonary hypertension (PH) is characterized by pulmonary artery remodeling that can
subsequently culminate in right heart failure and premature death. Emerging evidence …

Epithelial-mesenchymal transition (EMT) is a cellular biological process involved in
migration of primary cancer cells to secondary sites facilitating metastasis. Besides, EMT …

Hypoxia-inducible factor pathway genes are linked to adaptation in both human and
nonhuman highland species. EPAS1, a notable target of hypoxia adaptation, is associated …

The hypoxia-inducible factors (HIF) are transcription factors that activate the adaptive
hypoxic response when oxygen levels are low. The HIF transcriptional program increases …

The Hypoxia Inducible Factor 1 (HIF-1) plays a major role in the cellular response to hypoxia
by regulating the expression of many genes involved in adaptive processes that allow cell …

Hypoxia has been shown to increase the aggressiveness and severity of tumor progression.
Along with chronic and acute hypoxic regions, solid tumors contain regions of cycling …

COVID-19 pandemia is a major health emergency causing hundreds of deaths worldwide.
The high reported morbidity has been related to hypoxia and inflammation leading to …

Complex multicellular life in mammals relies on functional cooperation of different organs for
the survival of the whole organism. The kidneys play a critical part in this process through …

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. The initial stage
of CVDs is characterized by endothelial dysfunction, defined as the limited bioavailability of …

Abstract Angiopoietin-like 4 (ANGPTL4) is known to regulate various cellular and systemic
functions. However, its cell-specific role in endothelial cells (ECs) function and metabolic …