La pharmaco-résistance est un obstacle majeur au contrôle du paludisme en RDC. Deux
revues systématiques et trois études originales indiquent une résistance répandue du P …

Children in areas of highly seasonal malaria transmission in the Sahel should receive SMC
with sulfadoxine-pyrimethamine plus amodiaquine (SPAQ). These drugs retain their efficacy …

Background: Quinine remains the treatment of choice in hospitalized malaria cases;
however, adverse reactions and the long treatment duration of 7 days often hamper its …

Abstract Sulfadoxine-pyrimethamine (SP), the current first line antimalarial drug in Tanzania,
is compromised by evolution and spread of mutations in the parasite's dhfr and dhps genes …

La prévalence des mutations ponctuelles associées à la résistance à la sulfadoxine et à la
pyriméthamine a été déterminée par séquençage des fragments de gènes codant pour la …

Reactive oxygen species (ROS), such as hydrogen peroxide (H20 2), superoxide anion ('02-
) and the hydroxyl radical (· OH), are highly reactive towards DNA, lipids and proteins, often …

Background: The World Health Organization recommends intermittent preventive treatment
of malaria in pregnancy (IPTp) using sulphadoxine-pyrimethamine (SP) during antenatal …

Malaria remains one of the most prevalent and life-threatening diseases. It is caused by
infection with parasites of the genus Plasmodium and transmitted to humans through female …

MATERIALS AND METHODS A previously reported in-host dynamics model (9) was used to
simulate a P. falciparum infection in a malaria-naive human host. Simulations were …

In Gabon, sulfadoxine-pyrimethamine (SP) is recommended for intermittent preventive
treatment during pregnancy (IPTp-SP) and for uncomplicated malaria treatment through …