Since the discovery of the histamine H 3 receptor in 1983, tremendous advances in the
pharmacological aspects of H 3 receptor antagonists/inverse agonists have been …

In this chapter, we review the effects of global null mutant and overexpressing transgenic
mouse lines on voluntary self-administration of alcohol. We examine approximately 200 …

Military personnel deployed in combat operations are highly prone to develop Parkinson's
disease (PD) in later lives. PD largely involves dopaminergic pathways with hallmarks of …

The brain histamine system has been implicated in regulation of sensorimotor gating deficits
and in Gilles de la Tourette syndrome. Histamine also regulates alcohol reward and …

The histamine H 3 receptor (H 3 R), belonging to the family of G-protein-coupled receptors,
is predominantly expressed in the central nervous system (CNS). Since its discovery by …

Histamine has long been accepted as a pro-cognitive agent. However, lines of evidence
have suggested that the roles of histamine in learning and memory processes are much …

We have earlier found that the histamine H3 receptor (H3R) antagonism diminishes
motivational aspects of alcohol reinforcement in mice. Here we studied the role of H3Rs in …

It has become clear that histamine H 3 receptors (H 3 R) have been implicated in modulating
ethanol intake and preference in laboratory animals. The novel non-imidazole H 3 R …

A premature termination codon in the human histidine decarboxylase (Hdc) gene has been
identified in a family suffering from Guilles de la Tourette syndrome (GTS). In the current …

Substance use disorders are a leading cause of morbidity and mortality, and available
pharmacological treatments are of modest efficacy. Histamine is a biogenic amine with four …