Parental environmental factors, including diet, body composition, metabolism, and stress,
affect the health and chronic disease risk of people throughout their lives, as captured in the …

During fertilization, the egg and the sperm are supposed to contribute precisely one copy of
each chromosome to the embryo. However, human eggs frequently contain an incorrect …

The worldwide upward trend in obesity has been dramatic, now affecting more than 20% of
American women of reproductive age. Obesity is associated with many adverse maternal …

Bidirectional somatic cell–oocyte signaling is essential to create a changing intrafollicular
microenvironment that controls primordial follicle growth into a cohort of growing follicles …

Autophagy is a highly conserved catabolic process and a major cellular pathway for the
degradation of long-lived proteins and cytoplasmic organelles. An increasing body of …

Female reproductive capacity declines dramatically in the fourth decade of life as a result of
an age‐related decrease in oocyte quality and quantity. The primary causes of reproductive …

In the United States, 36.5% of women between the ages of 20 and 39 years are obese. This
obesity results in not only metabolic disorders including type II diabetes and cardiovascular …

Polycystic ovary syndrome (PCOS) is a prevalent hormonal disorder of premenopausal
women worldwide and is characterized by reproductive, endocrine, and metabolic …

This scientific statement summarizes the available preclinical, epidemiological, and clinical
trial evidence that supports the contributions of prepregnancy (and interpregnancy) …

Optimal energy production is required for oocyte and embryo development, and
mitochondrial abnormalities have devastating reproductive consequences. Improvement of …