Current hypotheses and theories regarding the pathogenesis of Alzheimer's disease (AD)
heavily implicate brain insulin resistance (IR) as a key factor. Despite the many well …

Ketones (principally β-hydroxybutyrate and acetoacetate (AcAc)) are an important
alternative fuel to glucose for the human brain, but their utilisation by the brain remains …

Alzheimer's disease (AD) is a major cause of dementia in older adults and is fast becoming
a major societal and economic burden due to an increase in life expectancy. Age seems to …

Alzheimer's disease (AD) is the most common form of dementia. Currently, there is no
effective medication for the prevention or treatment of AD. This has led to the search for …

Neuroketotherapeutics represent a class of bioenergetic medicine therapies that feature the
induction of ketosis. These therapies include medium-chain triglyceride supplements …

Epidemiological studies suggest that insulin resistance accelerates progression of age-
based cognitive impairment, which neuroimaging has linked to brain glucose …

Objective Glutamate mediated excitotoxicity, such as oxidative stress, neuroinflammation,
synaptic loss and neuronal death, is ubiquitous in Alzheimer's disease (AD). Our previous …

Several neurological diseases share pathological alterations, even though they differ in their
etiology. Neuroinflammation, altered brain glucose metabolism, oxidative stress …

Introduction/aim The brain in Alzheimer's disease shows glucose hypometabolism but may
utilize ketones for energy production. Ketone levels can potentially be boosted through oral …

Significance: Epidemiological studies indicate that metabolic disorders are associated with
an increased risk for Alzheimer's disease (AD). Metabolic remodeling occurs in the central …