Lauric acid stimulates ketone body production in the KT-5 astrocyte cell line

Y Nonaka, T Takagi, M Inai, S Nishimura… - Journal of oleo …, 2016 - jstage.jst.go.jp
Coconut oil has recently attracted considerable attention as a potential Alzheimer's disease
therapy because it contains large amounts of medium-chain fatty acids (MCFAs) and its …

A 3-month aerobic training program improves brain energy metabolism in mild Alzheimer's disease: preliminary results from a neuroimaging study

CA Castellano, N Paquet, IJ Dionne… - Journal of …, 2017 - content.iospress.com
Background: Aerobic training has some benefits for delaying the onset or progression of
Alzheimer's disease (AD). Little is known about the implication of the brain's two main fuels …

Effects of a low-carbohydrate ketogenic diet on reported pain, blood biomarkers and quality of life in patients with chronic pain: a pilot randomized clinical trial

R Field, F Pourkazemi, K Rooney - Pain Medicine, 2022 - academic.oup.com
Background A low-carbohydrate ketogenic diet has been reported to improve chronic pain
by reducing inflammation, oxidative stress, and sensitivity within the nervous system. The …

HIV-1 infection alters energy metabolism in the brain: Contributions to HIV-associated neurocognitive disorders

B Cotto, K Natarajanseenivasan, D Langford - Progress in neurobiology, 2019 - Elsevier
The brain is particularly sensitive to changes in energy supply. Defects in glucose utilization
and mitochondrial dysfunction are hallmarks of nearly all neurodegenerative diseases and …

[HTML][HTML] Ketogenic diets and Alzheimer's disease

KW Lange, KM Lange, E Makulska-Gertruda… - Food Science and …, 2017 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
decline in cognitive functions and associated with the neuropathological hallmarks of …

Brain glucose and ketone utilization in brain aging and neurodegenerative diseases

D Kapogiannis, KI Avgerinos - International review of neurobiology, 2020 - Elsevier
To meet its high energy demands, the brain mostly utilizes glucose. However, the brain has
evolved to exploit additional fuels, such as ketones, especially during prolonged fasting …

Brain insulin signalling, glucose metabolism and females' reproductive aging: A dangerous triad in Alzheimer's disease

AI Duarte, MS Santos, CR Oliveira, PI Moreira - Neuropharmacology, 2018 - Elsevier
Alzheimer's disease (AD) constitutes a major socioeconomic challenge due to its disabling
features and the rise in prevalence (especially among (peri) menopausal women and type 2 …

Harnessing the power of microbiome assessment tools as part of neuroprotective nutrition and lifestyle medicine interventions

M Toribio-Mateas - Microorganisms, 2018 - mdpi.com
An extensive body of evidence documents the importance of the gut microbiome both in
health and in a variety of human diseases. Cell and animal studies describing this …

A ketogenic supplement improves white matter energy supply and processing speed in mild cognitive impairment

M Roy, M Fortier, F Rheault, M Edde… - … Research & Clinical …, 2021 - Wiley Online Library
Introduction White matter (WM) energy supply is crucial for axonal function and myelin
maintenance. An exogenous source of ketones, the brain's alternative fuel to glucose …

Alzheimer's disease: from mitochondrial perturbations to mitochondrial medicine

S Cardoso, C Carvalho, SC Correia, RM Seiça… - Brain …, 2016 - Wiley Online Library
Age‐related neurodegenerative diseases such as Alzheimer's disease (AD) are distressing
conditions causing countless levels of suffering for which treatment is often insufficient or …