Amyloid-β (Aβ) senile plaques and neurofibrillary tangles of tau are generally recognized as
the culprits of Alzheimer's disease (AD) and related dementia. About 25 years ago, the …

Purpose The brain can utilise medium chain triglycerides (MCTs) as an alternative fuel to
glucose, and research has shown that MCT ingestion improves cognitive function in …

The brain is a highly demanding organ, utilizing mainly glucose but also ketone bodies as
sources of energy. Glucose transporter-1 (GLUT1) and monocarboxylates transporter-1 …

The classic ketogenic diet is a diet high in fat, low in carbohydrates, and well-adjusted
proteins. The reduction in glucose levels induces changes in the body's metabolism, since …

Ketones provide an alternative brain fuel and may be neuroprotective in older people. Little
is known of how to optimize the ketogenic effect of C8: 0–C10: 0 medium chain triglyceride …

The therapeutic use of ketone bodies (KB) against acute brain injury and neurodegenerative
disorders has lately been suggested by many studies. Several mechanisms responsible for …

The high energy demands of the poorly myelinated long axon hippocampal and cortical
neurons render these neurons selectively vulnerable to degeneration in Alzheimer's …

Background: Fasudil, a Rho kinase inhibitor, exerts therapeutic effects in a mouse model of
Alzheimer's disease (AD), a chronic neurodegenerative disease with progressive loss of …

Abstract Introduction Sporadic Alzheimer's disease (AD) is strongly correlated with impaired
brain glucose metabolism, which may affect AD onset and progression. Ketolysis has been …

The brain is an organ that consumes a lot of energy. In the brain, energy is required for
synaptic transmission, numerous biosynthetic processes and axonal transport in neurons …