Metabolic intervention strategy of epilepsy treatment has been gaining broader attention due
to accumulated evidence that hypometabolism, manifested in humans as reduced brain …

Medium-chain triglyceride (MCT) ketogenic diets increase ketone bodies, which are
believed to act as alternative energy substrates in the injured brain. Octanoic (C8: 0) and …

The prevalence of obesity tripled worldwide between 1975 and 2016, and it is projected that
half of the US population will be overweight by 2030. The obesity pandemic is attributed, in …

Background: White matter energy supply to oligodendrocytes and the axonal compartment is
crucial for normal axonal function. Although gray matter glucose hypometabolism is …

Alzheimer's disease and related dementias (ADRD) represent an increasingly urgent public
health concern, with an increasing number of baby boomers now at risk. Due to a lack of …

Oral ketone supplements have gained popularity in recent years. There is biological
rationale for a potential ergogenic effect of this type of supplement, as they might not only …

We aimed to longitudinally assess the relationship between changing brain energy
metabolism (glucose and acetoacetate) and cognition during healthy aging. Participants …

Background Mild cognitive impairment (MCI) is characterized by a decline in cognition and
mainly affects older individuals above the age of 60. The global incidence of MCI varies, but …

The decreased availability of metabolizable energy resources in the central nervous system
is hypothesized to be a key factor in the pathogenesis of Alzheimer's disease. More …

It is becoming evident that type 2 diabetes mellitus is affecting brain energy metabolism. The
importance of alternative substrates for the brain in type 2 diabetes mellitus is poorly …