Human papillomavirus (HPV) is involved in one of the at least 2 pathways leading to vulvar
squamous cell carcinoma (VSCC). Inactivation of p53 and retinoblastoma by the viral …

BACKGROUND: Two independent pathways in the development of vulvar squamous cell
carcinoma (VSCC) have been described, one related to and the other independent of high …

Condyloma acuminatum, intraepithelial neoplasia, and squamous cell carcinoma are three
relatively frequent vulvar lesions. Condyloma acuminatum is induced by low risk genotypes …

Proliferative verrucous leukoplakia (PVL) is defined as an aggressive, relentless and
recalcitrant form of leukoplakia that has a high propensity for malignant transformation. The …

Vulvar intraepithelial neoplasia (VIN) is classified into 2 clinicopathologic subtypes, classic,
related to human papillomavirus (HPV) infection and affecting relatively young women, and …

P16 is a tumor suppressor gene product, shown to be overexpressed in most cervical
carcinomas and dysplasias associated with high-risk human papilloma virus (HPV) infection …

We present the clinical and pathological findings of 6 women with intraepithelial neoplasia
of differentiated or simplex type (DVIN). The mean age was 68 years (range 55-82). One …

Aims Differentiated vulvar intraepithelial neoplasia (dVIN), the precursor lesion to human
papillomavirus‐independent vulvar squamous cell carcinoma (VSCC), can be difficult to …

Differentiated-type vulvar intraepithelial neoplasia (dVIN) is a non–human papilloma virus
(HPV)-related precursor lesion to vulvar squamous carcinoma. The terminology has only …

Vulvar cancer is a rare disease and no systematic screening is available. Therefore,
detection of vulvar cancer precursors relies on the presence of vulvar symptoms or the …