Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …

The emergence of bacterial resistance has motivated researchers to discover new
antibacterial agents. Nowadays, fluoroquinolones keep their status as one of the essential …

Introduction In the field of bioconjugates, the focus on antibody–drug conjugates (ADCs)
with novel payloads beyond the traditional categories of potent cytotoxic agents is …

Covering: 2016 to 2022 RNA polymerase (RNAP) is the central enzyme in bacterial gene
expression representing an attractive and validated target for antibiotics. Two well-known …

TNP-2198, a stable conjugate of a rifamycin pharmacophore and a nitroimidazole
pharmacophore, has been designed, synthesized, and evaluated as a novel dual-targeted …

The rise of antibiotic resistance and the decrease in the discovery of new antibiotics have
caused a global health crisis. Of particular concern is the fact that despite efforts to develop …

Background Due to the rapid development of antimicrobial resistance, the efficacy of most
Helicobacter pylori eradication therapies have progressively decreased to an unacceptable …

Antimicrobial resistance to modern antibiotics stimulates the search for new ways to
synthesize and modify antimicrobial drugs. The development of synthetic approaches that …

Many approaches are being pursued to address the major global health challenge posed by
the increasing resistance of pathogenic bacteria to antibacterial agents. One of the …

The serious spread of antibiotic-resistant staphylococcal aureus strains is alarming. This is
reflected by the measures governments and health related bodies are offering to ease …