Reactive oxygen species (ROS) is a term encompassing a group of highly reactive oxygen-
derived molecules. In physiological systems, ROS production exists in concert with …

c-Jun is a major component of the dimeric transcription factor activator protein-1 (AP-1), a
paradigm for transcriptional response to extracellular signaling, whose components are …

The role of N 6-methyladenosine (m6A) modifications in renal diseases is largely unknown.
Here, we characterized the role of N 6-adenosine-methyltransferase-like 3 (METTL3), whose …

Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci
for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this …

Elucidating the mechanism for high metastasis capacity of triple negative breast cancers
(TNBC) is crucial to improve treatment outcomes of TNBC. We have recently reported that …

Simple Summary The tumor microenvironment is a complex network comprised of
neoplastic and a variety of immune cells, proteins, and inflammatory mediators. Previous …

ABSTRACT NLRP3 inflammasome mainly controls interleukin-1β (IL-1β) secretion, leading
to cell death called pyroptosis constituting a major antiviral host defense and inflammatory …

Background Osteoarthritis (OA) is a degenerative disease closely related to aging.
Nevertheless, the role and mechanisms of aging in osteoarthritis remain unclear. This study …

The transcriptional machinery is composed of numerous factors that help to regulate gene
expression in cells. The function and the fundamental role of transcription factors in different …

Background High‐grade serous ovarian carcinoma (HGSOC) is the most common and
aggressive histotype of epithelial ovarian cancer. The heterogeneity and molecular basis of …