Uncontrolled cell survival, growth, angiogenesis and metastasis are essential hallmarks of
cancer. Genetic and biochemical data have demonstrated that the growth and motility factor …

Head and neck squamous cell carcinomas (HNSCCs) are caused by tobacco and alcohol
consumption and by infection with high-risk types of human papillomavirus (HPV). Tumours …

Because of the critical roles of aberrant signaling in cancer, both c-MET and ALK receptor
tyrosine kinases are attractive oncology targets for therapeutic intervention. The cocrystal …

Glioblastoma is one of the most devastating cancers, in which tumor cell infiltration into
surrounding normal brain tissue confounds clinical management. This review describes …

A wide variety of human malignancies exhibit sustained c-Met stimulation, overexpression,
or mutation, including carcinomas of the breast, liver, lung, ovary, kidney, and thyroid …

The MET pathway is dysregulated in many human cancers and promotes tumour growth,
invasion and dissemination. Abnormalities in MET signalling have been reported to …

Selective small-molecule kinase inhibitors have emerged over the past decade as an
important class of anti-cancer agents, and have demonstrated impressive clinical efficacy in …

Anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase in the insulin receptor
superfamily, was initially identified in constitutively activated oncogenic fusion forms–the …

Simple Summary Immunotherapies and molecularly targeted therapies have drastically
changed the therapeutic approach for unresectable advanced or metastatic melanoma. The …

Decorin, a member of the small leucine-rich proteoglycan gene family, impedes tumor cell
growth by down-regulating the epidermal growth factor receptor. Decorin has a complex …