Bio-synthesis of food additives and colorants-a growing trend in future food

L Sun, F Xin, HS Alper - Biotechnology Advances, 2021 - Elsevier
Food additives and colorants are extensively used in the food industry to improve food
quality and safety during processing, storage and packing. Sourcing of these molecules is …

Microbial chassis development for natural product biosynthesis

X Xu, Y Liu, G Du, R Ledesma-Amaro, L Liu - Trends in biotechnology, 2020 - cell.com
Engineering microbial cells to efficiently synthesize high-value-added natural products has
received increasing attention in recent years. In this review, we describe the pipeline to build …

Recent advances on 2′-fucosyllactose: physiological properties, applications, and production approaches

Y Zhu, L Wan, W Li, D Ni, W Zhang… - Critical Reviews in …, 2022 - Taylor & Francis
Abstract The trisaccharide, 2′-fucosyllactose (Fucα1-2Galβ1-4Glc; 2′-FL), is the most
abundant oligosaccharide in human milk. It has numerous significant biological properties …

Combinatorial metabolic engineering of Escherichia coli for de novo production of 2′-fucosyllactose

L Lin, M Gong, Y Liu, J Li, X Lv, G Du, L Liu - Bioresource Technology, 2022 - Elsevier
Fucosyllactose (2′-FL) is a kind of fucosylated lactose of human milk oligosaccharides
(HMOs). In this work, Escherichia coli MG1655 was metabolically engineered to increase …

Strategies for enhancing microbial production of 2′-fucosyllactose, the most abundant human milk oligosaccharide

Y Liu, Y Zhu, H Wang, L Wan, W Zhang… - Journal of Agricultural …, 2022 - ACS Publications
Human milk oligosaccharides (HMOs), a group of structurally diverse unconjugated glycans
in breast milk, act as important prebiotics and have plenty of unique health effects for …

[HTML][HTML] Synthetic biology for future food: research progress and future directions

X Lv, Y Wu, M Gong, J Deng, Y Gu, Y Liu, J Li, G Du… - Future Foods, 2021 - Elsevier
Food is essential to provide energy for human cellular metabolism, and is usually made from
plants or animals. Beside plants and animals, other important food sources are made by …

Sustainable bioproduction of natural sugar substitutes: Strategies and challenges

Y Xu, Y Wu, Y Liu, J Li, G Du, J Chen, X Lv… - Trends in Food Science & …, 2022 - Elsevier
Background With the features of safety, stabilization, and low/no calorie, natural sugar
substitutes have been widely used in food and beverage industries. Nevertheless, the low …

Multi‐level metabolic engineering of Escherichia coli for high‐titer biosynthesis of 2′‐fucosyllactose and 3‐fucosyllactose

M Li, C Li, Y Luo, M Hu, Z Liu… - Microbial …, 2022 - Wiley Online Library
Abstract Fucosyllactoses (FL), including 2′‐fucosyllactose (2′‐FL) and 3‐fucosyllactose
(3‐FL), have garnered considerable interest for their value in newborn formula and …

Engineering the Substrate Transport and Cofactor Regeneration Systems for Enhancing 2′-Fucosyllactose Synthesis in Bacillus subtilis

J Deng, L Gu, T Chen, H Huang, X Yin, X Lv… - ACS Synthetic …, 2019 - ACS Publications
Human milk oligosaccharides (HMOs) have been proven to be beneficial to infants' intestinal
health and immune systems. 2′-Fucosyllactose (2′-FL) is the most abundant and …

Efficient Production of 2′-Fucosyllactose from l-Fucose via Self-Assembling Multienzyme Complexes in Engineered Escherichia coli

L Wan, Y Zhu, G Chen, G Luo, W Zhang… - ACS Synthetic …, 2021 - ACS Publications
2′-Fucosyllactose (2′-FL) has been widely used as a nutritional additive in infant formula
due to its multifarious nutraceutical and pharmaceutical functions in neonate health. As …