Over the last 20 years, primary FSGS has emerged as one of the leading causes of
idiopathic nephrotic syndrome in adults, particularly among African Americans. In nephrotic …

Focal segmental glomerulosclerosis (FSGS) is a common cause of steroid-resistant
nephrotic syndrome in children and adults. Although FSGS is considered a podocyte …

Monogenic disorders result from defects in a single gene. According to Mendel's laws, these
disorders are inherited in either a recessive or dominant fashion. Autosomal-recessive …

Podocyte foot process effacement is characteristic of proteinuric renal diseases. In minimal
change nephrotic syndrome (MCNS) foot processes are diffusely effaced whereas the extent …

Genetic variation at the MYH9 locus is linked to the high incidence of focal segmental
glomerulosclerosis (FSGS) and non-diabetic end-stage renal disease among African …

Mutations of NPHS2, encoding podocin, are the main cause of autosomal recessive steroid-
resistant nephrotic syndrome (NS) presenting in childhood. Adult-onset steroid-resistant NS …

Mutations in the gene encoding canonical transient receptor potential-6 (TRPC6) channels
result in severe nephrotic syndromes that typically lead to end-stage renal disease. Many …

It is currently postulated that steroid-sensitive idiopathic nephrotic syndrome (SSNS) and
steroid-resistant idiopathic nephrotic syndrome (SRNS), which are not related to the …

Focal segmental glomerulosclerosis (FSGS) is a histologic lesion resulting from a variety of
pathogenic processes that cause injury to the podocytes. Recently, mutations in more than …

Genetic screening paradigms for congenital and infantile nephrotic syndrome are well
established; however, screening in adolescents has received only minor attention. To help …