Cell-free DNA (cfDNA) in the circulating blood plasma of patients with cancer contains
tumour-derived DNA sequences that can serve as biomarkers for guiding therapy, for the …

The success of checkpoint inhibitors has accelerated the clinical implementation of a vast
mosaic of single agents and combination immunotherapies. However, the lack of clinical …

Growing evidence suggests that aberrant epigenetic regulation of gene function is strongly
related to the genesis of cancer. Unlike genetic mutations, the ability to reprogram the …

Cancer immunotherapy (CI) is rapidly advancing and can now be considered to be the “fifth
pillar” of cancer therapy, joining the ranks of surgery, cytotoxic chemotherapy, radiation, and …

Cancer is the second leading cause of death in the world, behind only cardiovascular
diseases, and is one of the most serious diseases threatening human health nowadays …

Novel immunotherapy approaches have provided durable remission in a significant number
of cancer patients with cancers previously considered rapidly lethal. Nonetheless, the high …

PURPOSE The terms undertreatment and overtreatment are often used to describe
inappropriate management of older adults with cancer. We conducted a comprehensive …

Context Financial toxicity (FT) is used to describe the financial distress/hardship associated
with cancer and its treatment. Objectives The aim of this review was to explore the …

Introduction Preferred first-line treatment for patients with metastatic EGFR-mutant lung
cancer is osimertinib, yet it is not known whether patient outcomes may be improved by …

Cancer is the second largest cause of death worldwide with the number of new cancer
cases predicted to grow significantly in the next decades. Biotechnology and medicine can …