Frailty is defined as a reduced physiologic reserve vulnerable to external stressors. For older
individuals, frailty plays a decisive role in increasing adverse health outcomes in most …

Older adults with cardiovascular disease (CVD) pose challenges to cardiac rehabilitation
(CR) clinicians because their disease is often coupled to physical frailty. Older patients with …

Background Age-related frailty is a multidimensional dynamic condition associated with
adverse patient outcomes and high costs for health systems. Several interventions have …

Background Sexual activity is important to the holistic health of older adults. However, the
sexual lives of older adults are understudied. We aimed to investigate the prevalence and …

Background Frailty is associated with early postoperative outcomes. How frailty influences
long-term postoperative recovery is poorly described. Our objective was to evaluate the …

Importance A frailty index has been proposed as a measure of aging among older
individuals. However, few studies have examined whether a frailty index measured at the …

Age-associated changes in DNA methylation have been implicated as 1 mechanism to
explain the development of frailty; however, previous cross-sectional studies of epigenetic …

Background Cardiac rehabilitation is a mainstay treatment for patients experiencing an
adverse cardiovascular event. Heart disease is important in frailty, but the impact of cardiac …

Background With emerging basic research evidence suggesting that fibroblast growth factor
(FGF) 21 is a catabolic molecule on muscle metabolism, we aimed to analyze the serum …

Background: Heyde syndrome is the co-occurrence of aortic stenosis and gastrointestinal
bleeding secondary to angiodysplasias. Surgical aortic valve replacement effectively …